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Ki67蛋白單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42207M
  • 中文名稱(chēng)：
    Ki67蛋白單克隆抗體
  • 英文名稱(chēng)：
    Mouse anti-Ki-67 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42207M-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Human(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,Flow-Cyt

  • BN42207M-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Human(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,Flow-Cyt

產(chǎn)品描述

英文名稱(chēng)Ki-67
中文名稱(chēng)Ki67蛋白單克隆抗體
別    名Antigen identified by monoclonal antibody Ki 67; Antigen KI67; KIA; Ki67; MKI67; Proliferation related Ki 67 antigen; Antigen KI-67; KI67_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  細(xì)胞周期蛋白  細(xì)胞分化  細(xì)胞類(lèi)型標(biāo)志物  表觀遺傳學(xué)  
抗體來(lái)源Mouse
克隆類(lèi)型Monoclonal
克 隆 號(hào)6B9
交叉反應(yīng)Human, Rat,  (predicted: Mouse, )
產(chǎn)品應(yīng)用IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量358kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Ki-67: 
亞    型IgG
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67 positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine labelling index. The correlation between low Ki67 index and histologically low grade tumours is strong. Ki67 is routinely used as a neuronal marker of cell cycling and proliferation.

Function:
Thought to be required for maintaining cell proliferation.

Subcellular Location:
Nucleus. Chromosome. Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes.

Similarity:
Contains 1 FHA domain.

SWISS:
P46013

Gene ID:
4288

Database links:
Entrez Gene: 4288 Human

Entrez Gene: 17345 Mouse

Entrez Gene: 246042 Rat

Omim: 176741 Human

SwissProt: P46013 Human

SwissProt: Q91VE6 Mouse

SwissProt: Q5RJM0 Rat

Unigene: 689823 Human

Unigene: 80976 Human

Unigene: 4078 Mouse

Unigene: 233802 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

細(xì)胞增殖標(biāo)志物(Proliferation Marker)
Ki67與PCNA一樣，為細(xì)胞增殖的一種標(biāo)記，在細(xì)胞凋亡中S、G2 、M期均有表達(dá)，G0期缺如。 Ki-67增殖指數(shù)高低與許多腫瘤的分化程度、浸潤(rùn)、轉(zhuǎn)移以及預(yù)后密切相關(guān)，因此被廣泛作為各種惡性腫瘤的必檢項(xiàng)目之一。