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磷酸化GATA結合蛋白3重組兔單克隆抗體
  • 產品貨號：
    BN42093R
  • 中文名稱：
    磷酸化GATA結合蛋白3重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-phospho-GATA3 (Ser308) Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

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  • BN42093R-50ul

    50ul

    ￥2020.00

    交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

  • BN42093R-100ul

    100ul

    ￥3240.00

    交叉反應：Human 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

產品描述

英文名稱phospho-GATA3 (Ser308)
中文名稱磷酸化GATA結合蛋白3重組兔單克隆抗體
別    名GATA3 (phospho S308); p-GATA3 (phospho S308); GATA3 (phospho Ser308); p-GATA3 (Ser308); GATA 3; GATA3; GATA-3; GATA binding factor 3; GATA binding protein 3; HDR; MGC2346; MGC5199; MGC5445; Trans acting T cell specific transcription factor GATA 3; GATA3_HUMAN; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3.  
產品類型磷酸化抗體 
研究領域腫瘤  細胞生物  發(fā)育生物學  神經生物學  信號轉導  轉錄調節(jié)因子  t-淋巴細胞  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號3A1
交叉反應Human, 
產品應用WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 Flow-Cyt=2ug/Test ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human GATA3 around the phosphorylation site of Ser308:RL(pS)AA  
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites.

Function:
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.

Subcellular Location:
Nucleus.

Tissue Specificity:
T-cells and endothelial cells.

DISEASE:
Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.

Similarity:
Contains 2 GATA-type zinc fingers.

SWISS:
P23771

Gene ID:
2625

Database links:

Entrez Gene: 2625 Human

Entrez Gene: 14462 Mouse

Entrez Gene: 85471 Rat

Omim: 131320 Human

SwissProt: P23771 Human

SwissProt: P23772 Mouse

Unigene: 524134 Human

Unigene: 313866 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications