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線粒體鈣吸收蛋白單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42015M
  • 中文名稱：
    線粒體鈣吸收蛋白單克隆抗體
  • 英文名稱：
    Mouse anti-CBARA1/MICU1 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN42015M-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB

  • BN42015M-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱CBARA1/MICU1
中文名稱線粒體鈣吸收蛋白單克隆抗體
別    名Mitochondrial Calcium Uptake 1; Calcium-Binding Atopy-Related Autoantigen 1; Atopy-Related Autoantigen CALC; Ara CALC; CBARA1; CALC; Calcium Binding Atopy-Related Autoantigen 1; Calcium Uptake Protein 1, Mitochondrial; Allergen Hom S 4; EFHA3; MPXPS; MICU1_HUMAN;   
研究領(lǐng)域細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  新陳代謝  線粒體  
抗體來(lái)源Mouse
克隆類型Monoclonal
克 隆 號(hào)1H8
交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用WB=1:500-1000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
細(xì)胞定位細(xì)胞漿 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human CBARA1 Protein (1-250/476): 
亞    型IgG
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]

Function:
Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733).

Subunit:
Homohexamer; in absence of calcium (PubMed:24514027). Forms a homohexamer in absence of calcium and rearranges into a heterodimer in presence of calcium (PubMed:26489515, PubMed:24514027). Heterodimer; disulfide-linked; heterodimerizes with MICU2 (PubMed:24560927). The heterodimer formed with MICU2 associates with MCU at low calcium concentration and dissociates from MCU at high calcium level (PubMed:26387864). Component of the uniplex complex, composed of MCU, MCUB, MICU1, MICU2 and EMRE/SMDT1 (PubMed:24231807). Interacts (via polybasic region) with EMRE/SMDT1; the interaction is direct (PubMed:27099988). Interacts (via polybasic region) with MCU (via coiled coil domains); the interaction is direct and precedes formation of the heterodimer with MICU2 (PubMed:21685886, PubMed:23101630, PubMed:23178883, PubMed:24332854, PubMed:26387864). Interacts with SLC25A23 (PubMed:24430870). Interacts with CHCHD4/MIA40; which introduces the interchain disulfide bond with MICU2 (PubMed:26387864).

Subcellular Location:
Mitochondrion inner membrane; Single-pass membrane protein; Mitochondrion intermembrane space

Tissue Specificity:
Expressed in epithelial cell lines. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.

Similarity:
Belongs to the MICU1 family. MICU1 subfamily.
Contains 2 EF-hand domains.

SWISS:
Q9BPX6

Gene ID:
10367

Database links:

Entrez Gene: 507899 Cow

Entrez Gene: 479241 Dog

Entrez Gene: 10367 Human

Entrez Gene: 216001 Mouse

Entrez Gene: 365567 Rat

Omim: 605084 Human

SwissProt: Q0IIL1 Cow

SwissProt: Q9BPX6 Human

SwissProt: Q8VCX5 Mouse

SwissProt: Q6P6Q9 Rat

Unigene: 524367 Human

Unigene: 27199 Mouse

Unigene: 214252 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


























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