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膜糖蛋白CD200抗體
  • 產(chǎn)品貨號(hào)：
    BN41932R
  • 中文名稱：
    膜糖蛋白CD200抗體
  • 英文名稱：
    Rabbit anti-CD200 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41932R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41932R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41932R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Rat(predicted:Mouse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱CD200
中文名稱膜糖蛋白CD200抗體
別    名CD200; CD200 antigen; CD200 molecule; MOX1; MOX2; MRC; MRC OX 2 antigen; My033; OX 2; OX 2 membrane glycoprotein precursor; OX-2 membrane glycoprotein; OX2G; OX2G_HUMAN.  


研究領(lǐng)域細(xì)胞生物  免疫學(xué)  細(xì)胞表面分子  糖蛋白  淋巴細(xì)胞  t-淋巴細(xì)胞  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CD200:41-140/278 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Function:
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.

Subunit:
Interacts with CD200R1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

SWISS:
P41217

Gene ID:
4345

Database links:

Entrez Gene: 4345 Human

Omim: 155970 Human

SwissProt: P41217 Human

Unigene: 79015 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD200是Ⅰ型膜糖蛋白，為免疫球蛋白超家族的新成員，廣泛表達(dá)在人類胸腺細(xì)胞、B細(xì)胞、激活的T細(xì)胞、濾泡狀樹(shù)突細(xì)胞、神經(jīng)元及血管內(nèi)皮上?？杀磉_(dá)于B細(xì)胞及其增殖性疾病和一部分T細(xì)胞。近年來(lái)研究發(fā)現(xiàn)，CD200與CD200R間的相互作用可以傳遞抑制性信號(hào)減低髓樣細(xì)胞的活性，改變其遷移。CD200在免疫疾病和抑制排斥反應(yīng)中作為一種免疫耐受信號(hào)，它的一些相關(guān)分子在免疫調(diào)節(jié)中也具有一定的作用。