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T淋巴細胞轉(zhuǎn)錄調(diào)節(jié)因子TFEB抗體
  • 產(chǎn)品貨號：
    BN41921R
  • 中文名稱：
    T淋巴細胞轉(zhuǎn)錄調(diào)節(jié)因子TFEB抗體
  • 英文名稱：
    Rabbit anti-TFEB Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41921R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41921R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41921R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱TFEB
中文名稱T淋巴細胞轉(zhuǎn)錄調(diào)節(jié)因子TFEB抗體
別    名Alpha TFEB; AlphaTFEB; bHLHe35; T cell transcription factor EB; T-cell transcription factor EB; TCFEB; Transcription factor EB; TFEB_HUMAN.  
研究領域細胞生物  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  t-淋巴細胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量52kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TFEB:201-300/476 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.

Function:
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Subunit:
Homodimer and heterodimer; with TFE3 or MITF.

Subcellular Location:
Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus.

Post-translational modifications:
Sumoylated; does not affect dimerization with MITF.

Similarity:
Belongs to the MiT/TFE family.
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
P19484

Gene ID:
7942

Database links:

Entrez Gene: 7942 Human

Entrez Gene: 510032 Cow

Entrez Gene: 609046 Dog

Entrez Gene: 21425 Mouse

Entrez Gene: 100157940 Pig

Entrez Gene: 316214 Rat

Omim: 600744 Human

SwissProt: P19484 Human

SwissProt: Q9R210 Mouse

Unigene: 485360 Human

Unigene: 715310 Human

Unigene: 2305 Mouse

Unigene: 22098 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.