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生長分化因子9抗體
  • 產(chǎn)品貨號(hào)：
    BN41911R
  • 中文名稱：
    生長分化因子9抗體
  • 英文名稱：
    Rabbit anti-GDF9 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41911R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,Flow-Cyt,ELISA

  • BN41911R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,Flow-Cyt,ELISA

  • BN41911R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) 推薦應(yīng)用：WB,IHC-P,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱GDF9
中文名稱生長分化因子9抗體
別    名GDF9_HUMAN; GDF9; GDF-9; GDF 9; Growth differentiation factor 9.  
研究領(lǐng)域心血管  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  生長因子和激素  細(xì)胞分化  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量15kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GDF9:301-400/454 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹GDF 9 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell synthesized by ovarian somatic cells directly affect oocyte growth and function. GDF 9 is expressed in oocytes and is thought to be required for ovarian folliculogenesis.

Function:
Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.

Subunit:
Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity).

Subcellular Location:
Secreted (By similarity).

Tissue Specificity:
Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).

Post-translational modifications:
Phosphorylated; phosphorylation is critical for GDF9 function. In vitro, can be phosphorylated by CK at Ser-325.

DISEASE:
Note=Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins.

Similarity:
Belongs to the TGF-beta family.

SWISS:
O60383

Gene ID:
2661

Database links:

Entrez Gene: 2661 Human

Entrez Gene: 14566 Mouse

Entrez Gene: 59304 Rat

Omim: 601918 Human

SwissProt: O60383 Human

SwissProt: Q07105 Mouse

Unigene: 25022 Human

Unigene: 490461 Mouse

Unigene: 9714 Mouse

Unigene: 42874 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GDF9屬于轉(zhuǎn)移生長因子–β(TGF-β)及骨形態(tài)發(fā)生蛋白（BMP）家族成員。