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轉(zhuǎn)化生長因子β1抗體
  • 產(chǎn)品貨號(hào)：
    BN41902R
  • 中文名稱：
    轉(zhuǎn)化生長因子β1抗體
  • 英文名稱：
    Rabbit anti-TGF Beta 1+2+3 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41902R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat,Rabbit(predicted:Dog,Pig,Cow,Sheep,GuineaPig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41902R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat,Rabbit(predicted:Dog,Pig,Cow,Sheep,GuineaPig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41902R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat,Rabbit(predicted:Dog,Pig,Cow,Sheep,GuineaPig) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱TGF Beta 1+2+3
中文名稱轉(zhuǎn)化生長因子β1抗體
別    名TGF Beta 1/2/3; TGFβ1; TGFβ2; TGFβ3; CED; Diaphyseal dysplasia 1 progressive; DPD 1; DPD1; TGF beta 1; TGF beta; TGF beta1; TGF beta2; TGF beta3; TGF-beta 1; TGF-beta 2; TGF-beta 3; TGFB 1; TGFB; TGFB1; TGFB2; TGFB3; Transforming growth factor; Transforming growth factor beta 1; Transforming growth factor beta 2; Transforming growth factor beta 3; Transforming Growth Factor beta.  



研究領(lǐng)域腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, Rabbit,  (predicted: Dog, Pig, Cow, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2μg/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12.8/44kDa
細(xì)胞定位細(xì)胞外基質(zhì) 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TGF Beta 1:301-350/390 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The TGFBeta superfamily is composed of numerous growth and differentiation factors, including transforming growth factors Beta(TGFBeta)1,2 and 3; placental transforming growth factor (PTGFBeta);growth /differentiation factors (GDFs); mullerian inhibiting substance (MIS);bone morphogenic proteins (BMPs); glial cell line-derived neurotrophic factor (GDNF);inhibins or activins (Alpha,Beta-A, Beta-B and Beta-C),Lefty and Nodal. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis.

Function:
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

Subunit:
Homodimer; disulfide-linked, or heterodimer with TGFB2. Secreted and stored as a biologically inactive form in the extracellular matrix in a 290 kDa complex (large latent TGF-beta1 complex) containing the TGFB1 homodimer, the latency-associated peptide (LAP), and the latent TGFB1 binding protein-1 (LTBP1). The complex without LTBP1 is known as the'small latent TGF-beta1 complex'. Dissociation of the TGFB1 from LAP is required for growth factor activation and biological activity. Release of the large latent TGF-beta1 complex from the extracellular matrix is carried out by the matrix metalloproteinase MMP3. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling. Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with CD109, DPT and ASPN.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Highly expressed in bone. Abundantly expressed in articular cartilage and chondrocytes and is increased in osteoarthritis (OA). Co-localizes with ASPN in chondrocytes within OA lesions of articular cartilage.

Post-translational modifications:
Glycosylated.
The precursor is cleaved into mature TGF-beta-1 and LAP, which remains non-covalently linked to mature TGF-beta-1 rendering it inactive.

DISEASE:
Defects in TGFB1 are the cause of Camurati-Engelmann disease (CE) [MIM:131300]; also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.

Similarity:
Belongs to the TGF-beta family.

SWISS:
P01137

Gene ID:
7040

Database links:

Entrez Gene: 7040 Human

Entrez Gene: 21803 Mouse

Entrez Gene: 59086 Rat

Omim: 190180 Human

SwissProt: P01137 Human

SwissProt: P04202 Mouse

SwissProt: P17246 Rat

Unigene: 645227 Human

Unigene: 248380 Mouse

Unigene: 40136 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長因子和激素（ Growth Factor and Hormones） TGF是一種多效生長因子，對(duì)上皮細(xì)胞增值有潛在抑制作用，可抑制腫瘤生長用于許多惡性腫瘤如:胃癌、肺癌、膀胱癌、腎癌、前列腺癌、結(jié)腸癌等多種惡性腫瘤的研究。 TGFβ超級(jí)家族由為數(shù)眾多的生長的分化因子組成,包括轉(zhuǎn)移生長因子β1，2和3(TGF β1，TGF β2，TGF β3)；胎盤生長因子(PTGF-β)；生長/分化因子(GDFs)；繆氏抑制物(MIS)；骨形態(tài)形成蛋白(BMPs)；交織細(xì)胞元神經(jīng)生長因子(GDNF);抑制素和活化素(α, β-A,和β-C)，Lefty和Nodal。 TGF超級(jí)家族成員參與胚胎發(fā)育和成體組織體內(nèi)平衡。TGF-β1抗體與TGF-β2和TGF-β3沒有交叉反應(yīng)。與豚鼠有大部分交叉.



























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