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極低密度脂蛋白受體抗體
  • 產(chǎn)品貨號：
    BN41897R
  • 中文名稱：
    極低密度脂蛋白受體抗體
  • 英文名稱：
    Rabbit anti-VLDL Receptor Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41897R-50ul

    50ul

    ￥1486.00

    交叉反應：Human 推薦應用：WB,ICC

  • BN41897R-100ul

    100ul

    ￥2360.00

    交叉反應：Human 推薦應用：WB,ICC

  • BN41897R-200ul

    200ul

    ￥3490.00

    交叉反應：Human 推薦應用：WB,ICC

產(chǎn)品描述

英文名稱VLDL Receptor
中文名稱極低密度脂蛋白受體抗體
別    名Very low density lipoprotein receptor; VLDL R; VLDLR; VLDL-R; VLDLRCH.  
研究領域腫瘤  心血管  免疫學  神經(jīng)生物學  信號轉導  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, 
產(chǎn)品應用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量93kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human VLDL Receptor:551-650/873 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹VLDL (very low density lipoprotein) cholesterol is one of the three major types of cholesterol found in blood. VLDL receptor plays an essential role in triglyceride metabolism. It binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation.

Function:
Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).

Subunit:
Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17. Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.

Tissue Specificity:
Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Post-translational modifications:
Ubiquitinated at Lys-839 by MYLIP leading to degradation.

DISEASE:
Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1) [MIM:224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures.

Similarity:
Contains 3 EGF-like domains.
Contains 8 LDL-receptor class A domains.
Contains 6 LDL-receptor class B repeats.

SWISS:
P98155

Gene ID:
7436

Database links:

Entrez Gene: 7436 Human

Entrez Gene: 22359 Mouse

Entrez Gene: 25696 Rat

Omim: 192977 Human

SwissProt: P98155 Human

SwissProt: P98156 Mouse

SwissProt: P98166 Rat

Unigene: 370422 Human

Unigene: 4141 Mouse

Unigene: 9975 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.