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8-羥基鳥嘌呤DNA糖基化酶
  • 產(chǎn)品貨號：
    BN41874R
  • 中文名稱：
    8-羥基鳥嘌呤DNA糖基化酶
  • 英文名稱：
    Rabbit anti-OGG1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

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  • BN41874R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

  • BN41874R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

  • BN41874R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,ELISA

產(chǎn)品描述

英文名稱OGG1
中文名稱8-羥基鳥嘌呤DNA糖基化酶
別    名8 hydroxyguanine DNA glycosylase; 8 oxoguanine DNA glycosylase 1; 8-oxoguanine DNA glycosylase; AP lyase; DNA apurinic or apyrimidinic site lyase; DNA lyase; DNA-(apurinic or apyrimidinic site) lyase; HMMH; HOGG 1; HOGG1; MMH; MUTM; N-glycosylase; Ogg 1; OGH 1; OGH1; OGG1_HUMAN.  



研究領(lǐng)域細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  線粒體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38-47kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human OGG1/8 hydroxyguanine DNA glycosylase:151-250/424 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].

Function:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Subcellular Location:
Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.

Tissue Specificity:
Ubiquitous.

DISEASE:
Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.

Similarity:
Belongs to the type-1 OGG1 family.

SWISS:
O15527

Gene ID:
4968

Database links:

Entrez Gene: 4968 Human

Entrez Gene: 18294 Mouse

Omim: 601982 Human

SwissProt: O15527 Human

SwissProt: O08760 Mouse

Unigene: 380271 Human

Unigene: 43612 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.