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磺酰脲類藥物受體1抗體
  • 產(chǎn)品貨號(hào)：
    BN41871R
  • 中文名稱：
    磺酰脲類藥物受體1抗體
  • 英文名稱：
    Rabbit anti-SUR1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41871R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Horse,GuineaPig) 推薦應(yīng)用：WB,ELISA

  • BN41871R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Horse,GuineaPig) 推薦應(yīng)用：WB,ELISA

  • BN41871R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Horse,GuineaPig) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱SUR1
中文名稱磺酰脲類藥物受體1抗體
別    名ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.  


研究領(lǐng)域免疫學(xué)  細(xì)胞膜受體  藥物及化合物  糖尿病  內(nèi)分泌病  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Horse, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量175kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human SUR1:301-400/1581 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

Subunit:
Interacts with KCNJ11.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.

SWISS:
Q09428

Gene ID:
6833

Database links:

Entrez Gene: 6833 Human

Entrez Gene: 20927 Mouse

Entrez Gene: 25559 Rat

Omim: 600509 Human

SwissProt: Q09428 Human

SwissProt: Q09429 Rat

Unigene: 54470 Human

Unigene: 11187 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰島β細(xì)胞膜含有磺酰脲受體及與之相偶聯(lián)的ATP敏感的鉀通道Ik（ATP），以及電壓依賴性的鈣通道。當(dāng)磺酰脲類藥物與其受體相結(jié)合后，可阻滯Ik（ATP）而阻鉀外流，致使細(xì)胞膜去極化，增強(qiáng)電壓依賴性鈣通道開放，胞外鈣內(nèi)流。胞內(nèi)游離鈣濃度增加后，觸發(fā)胞吐作用及胰島素的釋放。














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