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孤兒核受體蛋白Nur77抗體
  • 產(chǎn)品貨號(hào)：
    BN41863R
  • 中文名稱：
    孤兒核受體蛋白Nur77抗體
  • 英文名稱：
    Rabbit anti-Nur77 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41863R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Horse,Cow,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41863R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Horse,Cow,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41863R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Horse,Cow,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Nur77
中文名稱孤兒核受體蛋白Nur77抗體
別    名GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; NGFIB; NP 10; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear Receptor Subfamily 4 Group A Member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; ST 59; ST59; Steroid receptor TR3; TR 3; TR3; TR3 orphan receptor; Early response protein NAK1.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  糖尿病  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Cow, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量66kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Nur77/GFRP:351-450/598 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Subunit:
Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Fetal muscle and adult liver, brain and thyroid.

Similarity:
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

SWISS:
P22736

Gene ID:
3164

Database links:

Entrez Gene: 3164 Human

Entrez Gene: 15370 Mouse

Entrez Gene: 79240 Rat

Omim: 139139 Human

SwissProt: P22736 Human

SwissProt: P12813 Mouse

SwissProt: P22829 Rat

Unigene: 524430 Human

Unigene: 119 Mouse

Unigene: 10000 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

孤兒核受體蛋白Nur77是早期反應(yīng)轉(zhuǎn)錄因子之一，多種刺激因子如缺氧可誘導(dǎo)其迅速表達(dá)，Nur77參與調(diào)控細(xì)胞增殖、存活、分化等過程。這類核受體是體內(nèi)廣泛分布的配體依賴性的轉(zhuǎn)錄因子，通過調(diào)控基因協(xié)調(diào)表達(dá)，在機(jī)體的生長(zhǎng)發(fā)育、新陳代謝，細(xì)胞分化及體內(nèi)許多生長(zhǎng)發(fā)育過程中發(fā)揮重要作用，其功能障礙將導(dǎo)致一系列疾病的發(fā)生，如；癌癥、糖尿病、肥胖、不孕不育等等。