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Klotho多肽蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41851R
  • 中文名稱：
    Klotho多肽蛋白抗體
  • 英文名稱：
    Rabbit anti-Klotho Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41851R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41851R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41851R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Klotho
中文名稱Klotho多肽蛋白抗體
別    名KL antibody KLOT_HUMAN; Klotho peptide.  
研究領(lǐng)域腫瘤  細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  新陳代謝  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量113kDa
細(xì)胞定位細(xì)胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Klotho:401-500/1012 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Function:
May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling (By similarity).

Subunit:
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide.
Isoform 2: Secreted.
Klotho peptide: Secreted.

Tissue Specificity:
Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.hepatocellular carcinomas, and in chronic renal failure kidney.

Post-translational modifications:
N-glycosylated.

DISEASE:
Present in cortical renal tubules (at protein level). Soluble peptide is Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC) [MIM:211900]. A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement.

Similarity:
Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

SWISS:
Q9UEF7

Gene ID:
9365

Database links:

Entrez Gene: 9365 Human

Entrez Gene: 16591 Mouse

Omim: 604824 Human

SwissProt: Q9UEF7 Human

SwissProt: O35082 Mouse

Unigene: 524953 Human

Unigene: 6500 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.