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乙酰輔酶A羧化酶抗體
  • 產(chǎn)品貨號：
    BN41847R
  • 中文名稱：
    乙酰輔酶A羧化酶抗體
  • 英文名稱：
    Rabbit anti-Acetyl Coenzyme A Carboxylase Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41847R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Cow,Monkey) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN41847R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Cow,Monkey) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN41847R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat,Cow,Monkey) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Acetyl Coenzyme A Carboxylase
中文名稱乙酰輔酶A羧化酶抗體
別    名Acetyl Coenzyme A Carboxylase; ACAS2; AceCS; Acetate CoA ligase; Acetyl CoA synthetase; Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; ACS; ACSA; ACSS2; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; EC 6.2.1.1; MYH7B; ACAC; ACACB; ACC alpha; ACC beta; ACC1; ACC2; ACCA; ACCB; Acetyl CoA carboxylase 1; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase alpha; Acetyl CoA carboxylase beta; Biotin carboxylase; COA1; COA2; HFA1; ACACB_HUMAN; ACACA_HUMAN; Acetyl Coenzyme A Carboxylase; Acetyl-CoA carboxylase 1; ACC1; ACC-alpha; Acetyl-CoA carboxylase 265; ACC-alpha; ACC-beta.  





研究領(lǐng)域腫瘤  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Cow, Monkey, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量265kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Acetyl Coenzyme A Carboxylase 1/2:2307-2355/2458 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Subunit:
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.

Subcellular Location:
Endomembrane system. Note=May associate with membranes.

Tissue Specificity:
Predominantly expressed in the heart, skeletal muscles and liver.

Similarity:
Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.

SWISS:
O00763

Gene ID:
31

Database links:

Entrez Gene: 31 Human

Entrez Gene: 32 Human

Entrez Gene: 100705 Mouse

Entrez Gene: 107476 Mouse

Entrez Gene: 116719 Rat

Entrez Gene: 60581 Rat

Omim: 200350 Human

Omim: 601557 Human

SwissProt: O00763 Human

SwissProt: Q13085 Human

SwissProt: Q5SWU9 Mouse

SwissProt: O70151 Rat

SwissProt: P11497 Rat

Unigene: 160556 Human

Unigene: 234898 Human

Unigene: 44372 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.