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促甲狀腺素釋放激素抗體
  • 產(chǎn)品貨號：
    BN41802R
  • 中文名稱：
    促甲狀腺素釋放激素抗體
  • 英文名稱：
    Rabbit anti-TRH/Prothyroliberin Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41802R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推薦應(yīng)用：WB

  • BN41802R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推薦應(yīng)用：WB

  • BN41802R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推薦應(yīng)用：WB

產(chǎn)品描述

英文名稱TRH/Prothyroliberin
中文名稱促甲狀腺素釋放激素抗體
別    名Thyrotropin releasing hormone; Protirelin; Thyroliberin [Precursor]; Thyroliberin; Thyrotropin releasing factor; TRF; TRH; TRH_HUMAN; TSH releasing factor; Prothyroliberin.  
研究領(lǐng)域腫瘤  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  內(nèi)分泌病  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TRH/Prothyroliberin:131-240/242 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013].

Function:
Thyrotropin releasing hormone (TRH) is a tripeptide hormone that stimulates the release of thyroid stimulating hormone and prolactin by the anterior pituitary. TRH is produced by the hypothalamus and travels across the median eminence to the pituitary via the hypophyseal portal system. In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal system and pancreatic islets.

Subcellular Location:
Secreted

Tissue Specificity:
Hypothalamus. Expressed in the hair follicle epithelium (at protein level).

Similarity:
Belongs to the TRH family.

SWISS:
P20396

Gene ID:
7200

Database links:

Entrez Gene: 7200 Human

Entrez Gene: 22044 Mouse

Entrez Gene: 25569 Rat

Omim: 275120 Human

SwissProt: P20396 Human

SwissProt: Q62361 Mouse

SwissProt: P01150 Rat

Unigene: 1363 Mouse

Unigene: 22 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

促甲狀腺激素釋放激素(TRH)是下丘腦合成及分泌的一種下丘腦激素，它可以促進垂體促甲狀腺激素的合成與分泌。促甲狀腺激素釋放激素的合成及分泌可以受血液中甲狀腺激素的調(diào)節(jié)。血液中甲狀腺激素增高(甲亢)可以抑制下丘腦促甲狀腺激素釋放激素(TRH)的生成，繼而使垂體促甲狀腺激素生成減少，甲狀腺激素增高也可以直接抑制垂體促甲狀腺激素的生成。血液中甲狀腺激素減少(甲低)可以興奮下丘腦促甲狀腺激素釋放激素(TRH)，繼而引起垂體促甲狀腺激素生成增加，甲狀腺激素減少還可以直接興奮垂體促甲狀腺激素的生成。

















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