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配對盒基因7抗體
  • 產(chǎn)品貨號(hào)：
    BN41799R
  • 中文名稱：
    配對盒基因7抗體
  • 英文名稱：
    Rabbit anti-PAX7 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

    產(chǎn)品規(guī)格

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  • BN41799R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P

  • BN41799R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P

  • BN41799R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P

產(chǎn)品描述

英文名稱PAX7
中文名稱配對盒基因7抗體
別    名Paired box gene 7; FLJ37460; HUP1; OTTHUMP00000002534; Paired box 7; Paired box homeotic gene 7; Paired box protein Pax-7; Paired domain gene 7; Paired domain gene HuP1; PAX7 transcriptional factor; PAX7/FKHR fusion gene, included; PAX7B; RGD1564360; PAX7_HUMAN.  



研究領(lǐng)域信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PAX7:141-240/520 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of PAX7 is unknown but it is speculated to be involved in tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown.

Function:
Probable transcription factor. May have a role in myogenesis.

Subunit:
Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX.

Subcellular Location:
Nucleus.

DISEASE:
Defects in PAX7 are a cause of rhabdomyosarcoma type 2 (RMS2) [MIM:268220]. It is a form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchimal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=A chromosomal aberration involving PAX7 is found in rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator.

Similarity:
Belongs to the paired homeobox family.
Contains 1 homeobox DNA-binding domain.
Contains 1 paired domain.

SWISS:
P23759

Gene ID:
5081

Database links:

Entrez Gene: 5081 Human

Entrez Gene: 18509 Mouse

Entrez Gene: 500574 Rat

Omim: 167410 Human

SwissProt: P23759 Human

SwissProt: P47239 Mouse

Unigene: 113253 Human

Unigene: 218760 Mouse

Unigene: 226327 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

同源結(jié)構(gòu)域蛋白（Homeodomain Proteins）
PAX-7屬于轉(zhuǎn)錄抑制因子。在胚胎發(fā)育和腫瘤生長中起關(guān)鍵作用。其突變和某些腫瘤的發(fā)病有關(guān)。