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5-羥色胺受體4抗體
  • 產(chǎn)品貨號：
    BN41781R
  • 中文名稱：
    5-羥色胺受體4抗體
  • 英文名稱：
    Rabbit anti-5HT4 Receptor Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41781R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41781R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41781R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Cow) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱5HT4 Receptor
中文名稱5-羥色胺受體4抗體
別    名5-HTR4 (5-hydroxytryptamine (serotonin) receptor 4a); Htr4a; 5-HT4; 5-HT4A; 5HT4; Htr45 HT 4; 5 HT4; 5 HT4R; 5 hydroxytryptamine 4 receptor; 5 hydroxytryptamine receptor 4; 5 hydroxytryptamine serotonin receptor 4; 5 hydroxytryptamine4 receptor; 5HT4; 5HT4R; Cardiac 5 HT4 receptor; HTR 4; HTR4; Serotonin 5 HT4 receptor; Serotonin receptor 4; 5HT4R_HUMAN.  



研究領(lǐng)域神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  通道蛋白  細(xì)胞膜受體  轉(zhuǎn)運(yùn)蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Cow, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human 5-HTR4:21-120/388 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described. [provided by RefSeq, May 2010]

Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Subunit:
Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with INADL, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.

Tissue Specificity:
soform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
Q13639

Gene ID:
3360

Database links:

Entrez Gene: 3360 Human

Entrez Gene: 15562 Mouse

Entrez Gene: 25324 Rat

GenBank: NP_000861.1 Human

Omim: 602164 Human

SwissProt: O70528 Guinea pig

SwissProt: Q13639 Human

SwissProt: P97288 Mouse

SwissProt: Q29006 Pig

SwissProt: Q62758 Rat

Unigene: 483773 Human

Unigene: 20440 Mouse

Unigene: 10094 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.