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鈉離子/?；悄懰峁厕D(zhuǎn)運(yùn)蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41764R
  • 中文名稱：
    鈉離子/?；悄懰峁厕D(zhuǎn)運(yùn)蛋白抗體
  • 英文名稱：
    Rabbit anti-SLC10A1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

    產(chǎn)品規(guī)格

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  • BN41764R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Rabbit,Horse,Dog,Rat,Mouse) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN41764R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Rabbit,Horse,Dog,Rat,Mouse) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN41764R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Rabbit,Horse,Dog,Rat,Mouse) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱SLC10A1
中文名稱鈉離子/?；悄懰峁厕D(zhuǎn)運(yùn)蛋白抗體
別    名Na+/taurocholate Cotransporting Polypeptide; Na(+)/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na / bile acid cotransporter; Na / taurocholate transport protein; Na(+)/taurocholate transport protein; NTCP; NTCP1; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1; Slc10a1 protein; Slc10a1; SBACT; SLC10A1; NTCP_HUMAN.  
研究領(lǐng)域免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)運(yùn)蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg /test ICC=1:100-500 IF=1:100-500 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NTCP:21-120/349 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization(SLC10A2; MIM 601295), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).[supplied by OMIM]

Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Liver and kidney

Similarity:
Belongs to the sodium:bile acid symporter family.

SWISS:
Q14973

Gene ID:
6554

Database links:

Entrez Gene: 6554 Human

Entrez Gene: 20493 Mouse

Entrez Gene: 24777 Rat

Omim: 182396 Human

SwissProt: Q14973 Human

SwissProt: O08705 Mouse

SwissProt: P26435 Rat

Unigene: 952 Human

Unigene: 341781 Mouse

Unigene: 9913 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NTCP（鈉離子/?；悄懰峁厕D(zhuǎn)運(yùn)蛋白）(鈉離子-?；悄懰峁厕D(zhuǎn)運(yùn)多肽)Na+/taurocholate Cotransporting Polypeptide是 肝臟的膽汁酸鹽吸收主要是鈉離子依賴性轉(zhuǎn)運(yùn)子NTCP介導(dǎo)的，主要吸收?；悄懰?，是肝細(xì)胞特有的一種轉(zhuǎn)運(yùn)載體，分布在肝細(xì)胞基側(cè)膜在肝小葉和肝的腺泡表達(dá)較多。
有學(xué)者認(rèn)為：NTCP是乙肝病毒的細(xì)胞表面受體分子，是HBV和HDV的功能受體，這些研究將有待于科研人員的進(jìn)一步證實(shí)。