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配對(duì)盒基因5抗體
  • 產(chǎn)品貨號(hào)：
    BN41757R
  • 中文名稱：
    配對(duì)盒基因5抗體
  • 英文名稱：
    Rabbit anti-PAX5 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41757R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Pig,Cow) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41757R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Pig,Cow) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41757R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Chicken,Pig,Cow) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱PAX5
中文名稱配對(duì)盒基因5抗體
別    名B cell lineage specific activator; B cell lineage specific activator protein; B cell specific activator protein; B cell specific transcription factor; B-cell-specific transcription factor; BSAP; EBB-1; KLP; Paired box 5; Paired box gene 5 (B cell lineage specific activator protein); Paired box gene 5 (B cell lineage specific activator); Paired box gene 5; Paired box homeotic gene 5; Paired box protein Pax 5; Paired box protein Pax-5; Paired domain gene 5; PAX 5; PAX5; PAX5_HUMAN; Transcription factor PAX 5.  
研究領(lǐng)域染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  表觀遺傳學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human PAX5:301-391/391 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.

Function:
May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

Subunit:
Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4. Interacts with ETS1, altering its DNA-binding properties.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

Post-translational modifications:
O-glycosylated (Probable).

DISEASE:
Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.

Similarity:
Contains 1 paired domain.

SWISS:
Q02548

Gene ID:
5079

Database links:

Entrez Gene: 5079 Human

Entrez Gene: 18507 Mouse

Omim: 167414 Human

SwissProt: Q02548 Human

SwissProt: Q02650 Mouse

Unigene: 654464 Human

Unigene: 439659 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

同源結(jié)構(gòu)域蛋白（Homeodomain Proteins）
PAX-5屬于轉(zhuǎn)錄抑制因子。在胚胎發(fā)育和腫瘤生長(zhǎng)中起關(guān)鍵作用。其突變和某些腫瘤的發(fā)病有關(guān)。Pax-5基因是B細(xì)胞生成和B細(xì)胞發(fā)育的重要轉(zhuǎn)錄因子，是B細(xì)胞系特異性激活蛋白。在B細(xì)胞早期發(fā)育階段，Pax-5能影響CD19、CD20等B細(xì)胞特異性基因的表達(dá)。它主要分布于前B細(xì)胞和成熟B細(xì)胞。該蛋白對(duì)B細(xì)胞和神經(jīng)元的發(fā)育有重要作用。





















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