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促黑細(xì)胞激素α抗體
  • 產(chǎn)品貨號(hào)：
    BN41755R
  • 中文名稱：
    促黑細(xì)胞激素α抗體
  • 英文名稱：
    Rabbit anti-alpha MSH Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41755R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Rabbit) 推薦應(yīng)用：WB,IHC-P,ELISA

  • BN41755R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Rabbit) 推薦應(yīng)用：WB,IHC-P,ELISA

  • BN41755R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Rabbit) 推薦應(yīng)用：WB,IHC-P,ELISA

產(chǎn)品描述

英文名稱alpha MSH
中文名稱促黑細(xì)胞激素α抗體
別    名MSH Alpha; alpha melanocyte stimulating hormone; Alpha MSH; Melanotropin alpha; POMC; proopiomelanocortin;Alpha-MSH; Melanotropin alpha; proopiomelanocortin; COLI_HUMAN.  


研究領(lǐng)域腫瘤  生長(zhǎng)因子和激素  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量1.4kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ACTH:138-150/267 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].

Function:
ACTH stimulates the adrenal glands to release cortisol.
MSH (melanocyte-stimulating hormone) increases thepigmentation of skin by increasing melanin production in melanocytes.
Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular Location:
Secreted.

Tissue Specificity:
ACTH and MSH are produced by the pituitary gland.

Similarity:
Belongs to the POMC family.

SWISS:
P01189

Gene ID:
5443

Database links:

Entrez Gene: 5443 Human

Entrez Gene: 18976 Mouse

Entrez Gene: 24664 Rat

Omim: 176830 Human

SwissProt: P01189 Human

SwissProt: P01193 Mouse

SwissProt: P01194 Rat

Unigene: 1897 Human

Unigene: 277996 Mouse

Unigene: 108195 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
















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