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緊密連接蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41722R
  • 中文名稱：
    緊密連接蛋白抗體
  • 英文名稱：
    Rabbit anti-OCLN Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41722R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,GuineaPig) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN41722R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,GuineaPig) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

  • BN41722R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse,GuineaPig) 推薦應(yīng)用：WB,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱OCLN
中文名稱緊密連接蛋白抗體
別    名Occludin, Occludin-1; Occludin1; Occludin 1; FLJ08163; BLCPMG; FLJ18079; FLJ77961; FLJ94056; MGC34277; Occludin; OCLN; OCLN_HUMAN; Tight junction protein occludin.   


研究領(lǐng)域細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  細(xì)胞粘附分子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=2μg/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量57kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse OCLN:431-522/522 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described. [provided by RefSeq].

Function:
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Subunit:
Interacts with TJP1/ZO1 and with VAPA.

Subcellular Location:
Membrane; Multi-pass membrane protein. Cell junction, tight junction.

Tissue Specificity:
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. May be phosphorylated by PKC during translocation to cell-cell contacts.

Similarity:
Belongs to the ELL/occludin family.
Contains 1 MARVEL domain.

SWISS:
Q61146

Gene ID:
18260

Database links:

Entrez Gene: 18260 Mouse

Entrez Gene: 100506658 Human

Entrez Gene: 397236 Pig

Entrez Gene: 83497 Rat

Entrez Gene: 403844 Dog

Omim: 602876 Human

SwissProt: Q28269 Dog

SwissProt: Q16625 Human

SwissProt: Q61146 Mouse

SwissProt: Q6P6T5 Rat

Unigene: 592605 Human

Unigene: 4807 Mouse

Unigene: 31429 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.