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酪蛋白激酶2相互作用蛋白1抗體
  • 產(chǎn)品貨號(hào)：
    BN41687R
  • 中文名稱：
    酪蛋白激酶2相互作用蛋白1抗體
  • 英文名稱：
    Rabbit anti-PLEKHO1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41687R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41687R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41687R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱PLEKHO1
中文名稱酪蛋白激酶2相互作用蛋白1抗體
別    名PLEKHO1; C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting protein 1; CK2 interacting protein 1 HQ0024c protein; CK2-interacting protein 1; CKIP-1; CKIP 1; CKIP1; JBP; OC120; Osteoclast maturation associated gene 120 protein; Pleckstrin homology domain containing family O member 1; PKHO1_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞凋亡  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CKIP-1:51-170/409 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2(CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Function:
Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Subunit:
Heterodimer or homodimer.

Subcellular Location:
Cell membrane. Nucleus. Cytoplasm. Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.

Tissue Specificity:
Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cancer cell lines such as MOLT-4, HEK293 and Jurkat cells.

Post-translational modifications:
C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage.

Similarity:
Contains 1 PH domain.

SWISS:
Q53GL0

Gene ID:
51177

Database links:

Entrez Gene: 51177 Human

Entrez Gene: 67220 Mouse

Entrez Gene: 310674 Rat

Omim: 608335 Human

SwissProt: Q53GL0 Human

SwissProt: Q9JIY0 Mouse

SwissProt: Q5BJM5 Rat

Unigene: 438824 Human

Unigene: 458147 Mouse

Unigene: 21037 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

酪蛋白激酶2相互作用蛋白1是近年來(lái)發(fā)現(xiàn)的一種重要分子，它通過(guò)與其他分子的相互作用在許多細(xì)胞行為中都發(fā)揮著重要的作用。 CKIP-1還具有促進(jìn)細(xì)胞凋亡的作用。CKIP-1可以與caspase-3形成正反饋環(huán)，增強(qiáng)腫瘤細(xì)胞的凋亡。