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淋巴管內(nèi)皮透明質(zhì)酸受體抗體
  • 產(chǎn)品貨號：
    BN41685R
  • 中文名稱：
    淋巴管內(nèi)皮透明質(zhì)酸受體抗體
  • 英文名稱：
    Rabbit anti-LYVE-1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41685R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,ELISA

  • BN41685R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,ELISA

  • BN41685R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse(predicted:Rat) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱LYVE-1
中文名稱淋巴管內(nèi)皮透明質(zhì)酸受體抗體
別    名LYVE1; lymphalic vessel endotheilial hyaluronan receptor 1; CRSBP 1; CRSBP1; extracellular link domain containing 1; extracellular link domain-containing 1; HAR; hyaluronic acid receptor; Cell surface retention sequence-binding protein 1; CRSBP-1; extracellular link domain-containing 1; Extracellular link domain-containing protein 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE1_MOUSE; Lymphatic endothelium specific hyaluronan receptor; LYVE 1; LYVE-1; XLKD1.  



研究領(lǐng)域心血管  細胞生物  免疫學(xué)  細胞類型標志物  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
細胞定位細胞漿 細胞膜 細胞外基質(zhì) 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse LYVE-1 terminus:231-318/318 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules have been identified that may be exploited as markers for lymphatic endothelium, including the hyaluronan receptor LYVE1, PALE, VEGFR3, podoplanin. LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

Function:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Subunit:
Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.

Post-translational modifications:
O-glycosylated.

Similarity:
Contains 1 Link domain.

SWISS:
Q9Y5Y7

Gene ID:
114332

Database links:

Entrez Gene: 10894 Human

Entrez Gene: 114332 Mouse

Omim: 605702 Human

SwissProt: Q9Y5Y7 Human

SwissProt: Q8BHC0 Mouse

Unigee: 246769 Human

Unigene: 655332 Human

Unigene: 396078 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

淋巴管標志物
LYVE-1是一種特異性氨基葡聚糖透明質(zhì)酸受體，均勻分布在淋巴管的管腔面和基底膜，目前多用于腫瘤淋巴轉(zhuǎn)移方面的研究。
淋巴管內(nèi)皮細胞透明質(zhì)酸受體1（LYVE1)LYVE1是位于淋巴管內(nèi)皮細胞上的含有322個氨基酸殘基的膜蛋白。與CD44糖蛋白同源，均勻分布于淋巴管內(nèi)外腔面，可與細胞外基質(zhì)的葡萄糖胺聚糖透明質(zhì)酸結(jié)合，具有從組織攝取透明質(zhì)酸鹽并轉(zhuǎn)運至淋巴液的作用。