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生長分化因子8抗體
  • 產品貨號：
    BN41679R
  • 中文名稱：
    生長分化因子8抗體
  • 英文名稱：
    Rabbit anti-GDF8 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41679R-50ul

    50ul

    ￥1486.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41679R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41679R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Pig,Cow,Horse,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱GDF8
中文名稱生長分化因子8抗體
別    名GDF 8; GDF-8; GDF8_HUMAN; Growth differentiation factor 8; Growth/Differentiation Factor 8; MSTN; myostatin; OTTHUMP00000163498.  
研究領域免疫學  生長因子和激素  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Chicken, Pig, Cow, Horse, Sheep, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12/43kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GDF8:281-375/375 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. Acts specifically as a negative regulator of skeletal muscle growth. [SUBUNIT] Homodimer; [TISSUE SPECIFICITY] Expressed specifically in developing and adult skeletal muscle. Weak expression in adipose tissue. Belongs to the TGF-beta family.

Function:
Acts specifically as a negative regulator of skeletal muscle growth.

Subunit:
Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.

Subcellular Location:
Secreted

Tissue Specificity:
Predominantly expressed in muscle. At hatching, expression is strongest in the skin epithelium, and is also found in the retina and brain. From day 28, expressed in skeletal muscle. In the adult, highest expression is seen in the gastrointestinal tract, brain, muscle, heart and testis. Also expressed in the adult pharynx, kidney, spleen, liver, gill, eyes, skin, swim bladder and ovary.

DISEASE:
Defects in MSTN are the cause of muscle hypertrophy (MSLHP) [MIM:614160]. MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong.

Similarity:
Belongs to the TGF-beta family.

SWISS:
O14793

Gene ID:
2660

Database links:

Entrez Gene: 2660 Human

Entrez Gene: 17700 Mouse

Entrez Gene: 373964 Chicken

Entrez Gene: 399534 Pig

Entrez Gene: 29152 Rat

Entrez Gene: 798441 Zebrafish

Omim: 601788 Human

SwissProt: O14793 Human

SwissProt: O08689 Mouse

SwissProt: O35312 Rat

SwissProt: O18830 Sheep

SwissProt: O42222 Zebrafish

Unigene: 41565 Human

Unigene: 3514 Mouse

Unigene: 44460 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

GDF-8又稱MSTN,是轉化生長因子超家族，也是近年來發(fā)現的一類重要的肌細胞生長調控因子，它通過抑制MyoD家族成員轉錄活性負向控制肌細胞的生長發(fā)育，它的表達量與肌肉重量的變化呈負相關。