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水通道蛋白-3抗體
  • 產(chǎn)品貨號：
    BN41675R
  • 中文名稱：
    水通道蛋白-3抗體
  • 英文名稱：
    Rabbit anti-AQP3 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41675R-50ul

    50ul

    ￥1486.00

    交叉反應：Human(predicted:Rat,Mouse) 推薦應用：WB,IHC-F,IF,Flow-Cyt,ELISA

  • BN41675R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Rat,Mouse) 推薦應用：WB,IHC-F,IF,Flow-Cyt,ELISA

  • BN41675R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Rat,Mouse) 推薦應用：WB,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱AQP3
中文名稱水通道蛋白-3抗體
別    名AQP 3; AQP3; Aquaporin 3 (GIL blood group); Aquaporin 3 (Gill blood group); Aquaporin3; Aquaporin-3; GIL; Gill blood group; AQP3_MOUSE.  
研究領域腫瘤  信號轉導  通道蛋白  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, 
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量32kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from mouse AQP3:201-292/292 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. [provided by RefSeq, Aug 2011]

Function:
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Renal medulla and colon. Predominantly in the inner medulla. Expressed in basal layer of epidermal keratinocytes.

Similarity:
Belongs to the MIP/aquaporin (TC 1.A.8) family.

SWISS:
Q8R2N1

Gene ID:
11828

Database links:

Entrez Gene: 360 Human

Entrez Gene: 11828 Mouse

Entrez Gene: 65133 Rat

Omim: 600170 Human

SwissProt: Q92482 Human

SwissProt: Q8R2N1 Mouse

SwissProt: P47862 Rat

Unigene: 234642 Human

Unigene: 34043 Mouse

Unigene: 11109 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

通道蛋白（Channel Protein）
AQP 3主要分布于腎臟集合管上皮細胞基側質(zhì)膜,除了對水有通透性外、還可轉運尿素和甘油等小分子物質(zhì),而尿素在尿液濃縮機制中有著重要的作用.
有學者認為：AQP-3的陽性率與某些腫瘤分化程度有關（胃癌、結腸癌、乳腺癌、前列腺癌、子宮癌、卵巢癌、甲狀腺癌等）