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信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體
  • 產(chǎn)品貨號：
    BN41664R
  • 中文名稱：
    信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體
  • 英文名稱：
    Rabbit anti-STAT6 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41664R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41664R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41664R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱STAT6
中文名稱信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子6抗體
別    名signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.  
研究領(lǐng)域腫瘤  發(fā)育生物學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/test  IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量94kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human STAT6:601-700/841 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.

Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.

Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif.

Subcellular Location:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Post-translational modifications:
Tyrosine phosphorylated following stimulation by IL-4 and IL-3.

Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.

SWISS:
P42226

Gene ID:
6778

Database links:

Entrez Gene: 6778 Human

Entrez Gene: 20852 Mouse

Entrez Gene: 362896 Rat

Omim: 601512 Human

SwissProt: P42226 Human

SwissProt: P52633 Mouse

Unigene: 524518 Human

Unigene: 121721 Mouse

Unigene: 6880 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信息轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子-6(signal transducer and activator of transcription-6，STAT6)是信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子(STAT)家族的一員，是一種94kD的蛋白質(zhì)。它通過JAK-STAT信號轉(zhuǎn)導(dǎo)途徑介導(dǎo)細胞因子IL-3、IL-4及IL-13誘導(dǎo)的基因表達，特別是在促進IL-4誘導(dǎo)的MHCⅡ類抗原及免疫球蛋白受體等的表達及Th2細胞和淋巴細胞的發(fā)育上發(fā)揮了重要的作用。