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多藥耐藥相關(guān)蛋白2抗體
  • 產(chǎn)品貨號：
    BN41649R
  • 中文名稱：
    多藥耐藥相關(guān)蛋白2抗體
  • 英文名稱：
    Rabbit anti-MRP2/ABCC2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41649R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41649R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41649R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱MRP2/ABCC2
中文名稱多藥耐藥相關(guān)蛋白2抗體
別    名multidrug resistance-associated protein2; ABC30; ABCC2; ATP binding cassette sub family C (CFTR/MRP) member 2; ATP binding cassette subfamily C member 2; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; CMOAT; CMOAT1; cMRP; DJS; KIAA1010; MRP 2; MRP-2; MRP2; Multidrug resistance associated protein 2; MRP2_HUMAN; ATP-binding cassette sub-family C member 2; Multidrug resistance-associated protein 2.   
研究領(lǐng)域腫瘤  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量174kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MRP2:485-615/1545 <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family.

Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.

DISEASE:
Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.

Similarity:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.

SWISS:
Q92887

Gene ID:
1244

Database links:

Entrez Gene: 1244 Human

Entrez Gene: 12780 Mouse

Entrez Gene: 25303 Rat

Omim: 601107 Human

SwissProt: Q92887 Human

SwissProt: Q8VI47 Mouse

SwissProt: Q63120 Rat

Unigene: 368243 Human

Unigene: 39054 Mouse

Unigene: 10265 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MRP-2作為一種結(jié)合輸出泵，轉(zhuǎn)運(yùn)許多不同的藥物結(jié)合物的蛋白。
MRP2蛋白的染色陽性產(chǎn)物分布于細(xì)胞漿/膜中。