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平足蛋白/淋巴管內(nèi)皮細(xì)胞蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41645R
  • 中文名稱：
    平足蛋白/淋巴管內(nèi)皮細(xì)胞蛋白抗體
  • 英文名稱：
    Rabbit anti-Podoplanin Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41645R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB,ELISA

  • BN41645R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB,ELISA

  • BN41645R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human(predicted:Mouse,Rat) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱Podoplanin
中文名稱平足蛋白/淋巴管內(nèi)皮細(xì)胞蛋白抗體
別    名Podoplanin Protein; AGGRUS; GLYCOPROTEIN 36 KD; Podoplanin; Glycoprotein 36; gp 36; GP 38; GP 40; gp36; GP38; GP40; HT1A 1; HT1A1; hT1alpha1; hT1alpha2; Lung type I cell membrane associated glycoprotein; Lung type I cell membrane associated glycoprotein isoform a; Lung type I cell membrane associated glycoprotein T1A 2; OTS 8; OTS8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; Podoplanin; T1 alpha; T1 ALPHA GENE; T1A; TIA 2; TIA2.  
研究領(lǐng)域腫瘤  心血管  細(xì)胞生物  免疫學(xué)  血管內(nèi)皮細(xì)胞  淋巴細(xì)胞  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量15kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Podoplanin:31-130/166 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Function:
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.

Tissue Specificity:
Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.

Post-translational modifications:
Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
The N-terminus is blocked.

Similarity:
Belongs to the podoplanin family.

SWISS:
Q86YL7

Gene ID:
14726

Database links:

Entrez Gene: 10630 Human

Entrez Gene: 14726 Mouse

Entrez Gene: 54320 Rat

Omim: 608863 Human

SwissProt: Q86YL7 Human

SwissProt: Q62011 Mouse

SwissProt: Q64294 Rat

Unigene: 468675 Human

Unigene: 2976 Mouse

Unigene: 794 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.




















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