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神經(jīng)粘蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41638R
  • 中文名稱：
    神經(jīng)粘蛋白抗體
  • 英文名稱：
    Rabbit anti-Neurocan Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41638R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41638R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41638R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Neurocan
中文名稱神經(jīng)粘蛋白抗體
別    名Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein; NCAN_HUMAN. 


研究領(lǐng)域發(fā)育生物學(xué)  神經(jīng)生物學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量140kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Neurocan:1185-1257/1257 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain. It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development. Neurocan expression in the brain is developmentally regulated. Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each. Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains. By virtue of their high expression at sites of neural damage and trauma, chondroitin sulfate proteoglycans, including neurocan, are thought to inhibit successful nerve regeneration. Alternative names: Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein.

Function:
May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid.

Subcellular Location:
Secreted.

Tissue Specificity:
Brain.

Similarity:
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 C-type lectin domain.
Contains 2 EGF-like domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 2 Link domains.
Contains 1 Sushi (CCP/SCR) domain.

SWISS:
P55066

Gene ID:
1463

Database links:

Entrez Gene: 1463 Human

Entrez Gene: 58982 Rat

Omim: 600826 Human

SwissProt: O14594 Human

SwissProt: P55067 Rat

Unigene: 169047 Human

Unigene: 10177 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)生物學(xué)相關(guān)蛋白（Neurobiology）
神經(jīng)粘蛋白(Neurocan)是由神經(jīng)元分泌的特異性蛋白質(zhì),廣泛分布于神經(jīng)系統(tǒng),可與神經(jīng)元細(xì)胞膜上特異性受體神經(jīng)粘附分子和神經(jīng)元膠質(zhì)細(xì)胞黏附分子結(jié)合,調(diào)節(jié)細(xì)胞連接,影響軸突生長(zhǎng).而在中樞神經(jīng)系統(tǒng)損傷后,Neurocan的表達(dá)增加,并抑制軸突生長(zhǎng).Neurocan在中樞神經(jīng)系統(tǒng)的形成和損傷后的修復(fù)都扮演著重要的角色.