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骨形態(tài)發(fā)生蛋白2抗體
  • 產(chǎn)品貨號(hào)：
    BN41617R
  • 中文名稱：
    骨形態(tài)發(fā)生蛋白2抗體
  • 英文名稱：
    Rabbit anti-BMP2 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41617R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41617R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41617R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Cow,Horse,Rabbit,Sheep) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱BMP2
中文名稱骨形態(tài)發(fā)生蛋白2抗體
別    名Bone morphogenetic protein 2; BMP 2; BMP 2A; BMP2A; BMP-2; BMP2_HUMAN.  
研究領(lǐng)域細(xì)胞生物  免疫學(xué)  發(fā)育生物學(xué)  神經(jīng)生物學(xué)  生長(zhǎng)因子和激素  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量13/44kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human BMP2:283-365/396 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily of secreted growth factors. It is a disulfide-linked homodimer and induces bone and cartilage formation. In addition to its osteogenic activity, BMP2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. BMPs control fundamental events in early embryonic development, organogenesis and adult tissue homeostasis.

Function:
Induces cartilage and bone formation.

Subunit:
Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with GREM2, RGMA, RGMB and RGMC. Interacts with ASPN.

Subcellular Location:
Secreted.

Tissue Specificity:
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.

Similarity:
Belongs to the TGF-beta family.

SWISS:
P12643

Gene ID:
650

Database links:

Entrez Gene: 650 Human

Entrez Gene: 12156 Mouse

Entrez Gene: 29373 Rat

Omim: 112261 Human

SwissProt: P12643 Human

SwissProt: P21274 Mouse

SwissProt: P49001 Rat

Unigene: 73853 Human

Unigene: 103205 Mouse

Unigene: 90931 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經(jīng)干細(xì)胞標(biāo)志物
BMP-2主要對(duì)未分化間充質(zhì)細(xì)胞和骨系細(xì)胞起到募集和分化作用。在骨形成早期，BMP-2不僅可使未分化間質(zhì)細(xì)胞向骨形成中心募集，并分化為骨系細(xì)胞，而且可使成纖維細(xì)胞、成肌細(xì)胞及骨髓的基細(xì)胞逆轉(zhuǎn)分化為骨系細(xì)胞。其主要過(guò)程是：增加或抑制這些細(xì)胞內(nèi)的某些特異性蛋白的分泌，使成纖維細(xì)胞分化為成骨細(xì)胞，成肌細(xì)胞快速分化為肥大的軟骨細(xì)胞，并促進(jìn)基質(zhì)鈣化。
對(duì)于成骨細(xì)胞，BMP-2則可使之維持其特有細(xì)胞表型，并誘導(dǎo)成骨細(xì)胞標(biāo)志物的增高，促進(jìn)細(xì)胞外基質(zhì)鈣化。在骨形成后期，BMP-2還作為一種破骨細(xì)胞分化因子與其它支持破骨細(xì)胞分化因子直接或間接刺激破骨細(xì)胞分化，參與骨的重建。