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多巴胺受體D1抗體
  • 產(chǎn)品貨號：
    BN41614R
  • 中文名稱：
    多巴胺受體D1抗體
  • 英文名稱：
    Rabbit anti-Dopamine Receptor D1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41614R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41614R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41614R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Dopamine Receptor D1
中文名稱多巴胺受體D1抗體
別    名DRD1; dopamine D1 receptor; D(1A) dopamine receptor; D1A dopamine receptor; Dopamine D1Receptors; D1DR; DADR; Dopamine Receptor D1; DR D1; DR D1A; DRD 1; DRD1 receptor; DRD1; DRD1A; DRD1_HUMAN; D(1A) dopamine receptor; DRD 1A; DRD1.  



研究領(lǐng)域腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat, 
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human DRD1:101-200/446 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]

Function:
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

Subunit:
Interacts with DNAJC14 via its C-terminus. Interacts with DRD1IP.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue Specificity:
Detected in caudate, nucleus accumbens and in the olfactory tubercle.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P21728

Gene ID:
1812

Database links:

Entrez Gene: 1812 Human

Entrez Gene: 13488 Mouse

Entrez Gene: 24316 Rat

Omim: 126449 Human

SwissProt: P21728 Human

SwissProt: Q61616 Mouse

SwissProt: P18901 Rat

Unigene: 2624 Human

Unigene: 54161 Mouse

Unigene: 24039 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

多巴胺受體D1在運動協(xié)調(diào)方面起重要作用，該受體的缺失對黑質(zhì)多巴胺能神經(jīng)元的影響程度雖沒臨床帕金森?。≒D）嚴(yán)重，但仍可加速多巴胺能神經(jīng)元發(fā)生退行性改變.該蛋白目前主要用于神經(jīng)退行性改變的研究。