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β-酪蛋白抗體
  • 產(chǎn)品貨號：
    BN41610R
  • 中文名稱：
    β-酪蛋白抗體
  • 英文名稱：
    Rabbit anti-Beta-casein Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41610R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Cow,Goat(predicted:Sheep) 推薦應用：WB,ELISA

  • BN41610R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Cow,Goat(predicted:Sheep) 推薦應用：WB,ELISA

  • BN41610R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Cow,Goat(predicted:Sheep) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱Beta-casein
中文名稱β-酪蛋白抗體
別    名Beta-casein; Casoparan; Antioxidant peptide; Casohypotensin; CASB; CASB_BOVIN; Casein beta; CSN 2; Csn2; CASB_BOVIN.  
研究領域細胞生物  免疫學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Cow, Goat,  (predicted: Sheep, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
細胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from cow Beta-casein:16-100/224 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Multiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regulated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insulin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regulator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation

Function:
Important role in determination of the surface properties of the casein micelles.
Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.
Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.
Antioxidant peptide has antioxidant activity.

Subcellular Location:
Secreted.

Tissue Specificity:
Mammary gland specific. Secreted in milk.

Similarity:
Belongs to the beta-casein family.

SWISS:
P11839

Gene ID:
443391

Database links:

Entrez Gene: 1447 Human

Entrez Gene: 281099 Bovin

Entrez Gene: 443391 Sheep

Omim: 115460 Human

SwissProt: P05814 Human

SwissProt: P02666 Bovin

Unigene: 2242 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.