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白細(xì)胞介素10抗體
  • 產(chǎn)品貨號(hào)：
    BN41576R
  • 中文名稱：
    白細(xì)胞介素10抗體
  • 英文名稱：
    Rabbit anti-IL-10 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41576R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41576R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41576R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Human(predicted:GuineaPig,Sheep,Rabbit,Pig,Chicken,Rat) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱IL-10
中文名稱白細(xì)胞介素10抗體
別    名Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. 


研究領(lǐng)域細(xì)胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse,  (predicted: Rat, Chicken, Pig, Rabbit, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量18kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IL-10:101-178/178 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

Function:
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Subunit:
Homodimer.

Subcellular Location:
Secreted.

Tissue Specificity:
Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Similarity:
Belongs to the IL-10 family.

SWISS:
P18893

Gene ID:
3586

Database links:

Entrez Gene: 3586 Human

Entrez Gene: 16153 Mouse

Entrez Gene: 25325 Rat

Omim: 124092 Human

SwissProt: P22301 Human

SwissProt: P18893 Mouse

SwissProt: P29456 Rat

Unigene: 193717 Human

Unigene: 874 Mouse

Unigene: 9868 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

白細(xì)胞介素-10(IL-10)是主要由Th2細(xì)胞所產(chǎn)生的一種細(xì)胞因子，活化的B細(xì)胞、單核巨噬細(xì)胞和枯否氏細(xì)胞（Kupffer's cell）等也可產(chǎn)生IL-10。它是以抑制Th細(xì)胞克隆細(xì)胞因子合成為特點(diǎn)的多效免疫調(diào)節(jié)因子。
白介素-10是維護(hù)細(xì)胞因子網(wǎng)絡(luò)平衡的重要負(fù)調(diào)節(jié)因子。其作用機(jī)制可能是降低抗原遞呈細(xì)胞MHCⅡ類抗原表達(dá)，或誘導(dǎo)抗原遞呈細(xì)胞產(chǎn)生另一種細(xì)胞因子，改變細(xì)胞內(nèi)信號(hào)傳遞途徑，從而選擇性抑制某些細(xì)胞因子mRNA轉(zhuǎn)錄，并與Th2細(xì)胞產(chǎn)生的IL-4、IL-5有協(xié)同作用。