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間隙連接蛋白43抗體
  • 產(chǎn)品貨號：
    BN41570R
  • 中文名稱：
    間隙連接蛋白43抗體
  • 英文名稱：
    Rabbit anti-Connexin 43 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41570R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat,Dog(predicted:Chicken,Cow) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41570R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat,Dog(predicted:Chicken,Cow) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41570R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat,Dog(predicted:Chicken,Cow) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Connexin 43
中文名稱間隙連接蛋白43抗體
別    名Connexin 43; connexin43; Connexin43v; Cx 43v; CX43; CX 43; CX-43; DFNB38; Gap junction 43 kDa heart protein;Connexin-43; Gap junction alpha 1 protein; Gap junction protein alpha 1 43kDa (connexin 43); Gap junction protein alpha 1 43kDa; Gap junction protein alpha like; GJA 1; GJA1; GJA-1; GJAL; HGNC:4282; HGNC:8112; Oculodentodigital dysplasia; ODD; ODOD; SDTY3; Syndactyly type III; CXA1_HUMAN.  




研究領域腫瘤  免疫學  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, Dog,  (predicted: Chicken, Cow, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
細胞定位細胞漿 細胞膜 細胞外基質(zhì) 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Connexin-43:211-260/382 human <Cytoplasmic>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq].

Function:
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract.

Subunit:
A connexon is composed of a hexamer of connexins. Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts with UBQLN4. Interacts with SGSM3. Interacts with KIAA1432/CIP150. Interacts with CNST and CSNK1D.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Tissue Specificity:
Expressed in the heart and fetal cochlea.

Post-translational modifications:
Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity. Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly.

DISEASE:
Defects in GJA1 are the cause of autosomal dominant oculodentodigital dysplasia (ODDD) [MIM:164200]; also known as oculodentoosseous dysplasia. ODDD is a highly penetrant syndrome presenting with craniofacial (ocular, nasal, dental) and limb dysmorphisms, spastic paraplegia, and neurodegeneration. Craniofacial anomalies tipically include a thin nose with hypoplastic alae nasi, small anteverted nares, prominent columnella, and microcephaly. Brittle nails and hair abnormalities of hypotrichosis and slow growth are present. Ocular defects include microphthalmia, microcornea, cataracts, glaucoma, and optic atrophy. Syndactyly type 3 and conductive deafness can occur in some cases. Cardiac abnormalities are observed in rare instances.

Similarity:
Belongs to the connexin family. Alpha-type (group II) subfamily.

SWISS:
P17302

Gene ID:
2697

Database links:

Entrez Gene: 2697 Human

Entrez Gene: 14609 Mouse

Entrez Gene: 24392 Rat

Omim: 121014 Human

SwissProt: P17302 Human

SwissProt: P23242 Mouse

SwissProt: P08050 Rat

Unigene: 74471 Human




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

間隙連接蛋白-43(Gap junction alpha-1 protein; GJA-1; (Vascular smooth muscle connexin-43))是構(gòu)成細胞間的通道，小分子成份可以借此在細胞間擴散。Connexin-43也是心肌縫隙連接的主要蛋白之一。
此外，星形細胞、成纖維細胞、平滑肌和腎等組織也有表達Connexin 43.