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鈣/鈣調(diào)素依賴蛋白激酶2b/2γ抗體
  • 產(chǎn)品貨號：
    BN41549R
  • 中文名稱：
    鈣/鈣調(diào)素依賴蛋白激酶2b/2γ抗體
  • 英文名稱：
    Rabbit anti-CAMK2A + CAMK2B + CAMK2D Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41549R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ELISA

  • BN41549R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ELISA

  • BN41549R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat 推薦應用：WB,IHC-P,IHC-F,ELISA

產(chǎn)品描述

英文名稱CAMK2A + CAMK2B + CAMK2D
中文名稱鈣/鈣調(diào)素依賴蛋白激酶2b/2γ抗體
別    名CaMK2 beta+gamma+delta; CaMK2 beta; CaMK2 gamma; CaMK2 delta; CAMK2G; Calcium/calmodulin dependent protein kinase (CaM kinase) II beta; Calcium/calmodulin dependent protein kinase II beta; Calcium/calmodulin dependent protein kinase IIB; Calcium/calmodulin dependent protein kinase type II beta chain; CAM 2; CaM kinase II beta chain; CaM kinase II beta subunit; CAM2; CAMK 2; CAMK 2B; CaMK II beta subunit; CaMK II subunit beta; CAMK2; CaMK2 beta; CAMK2B; CAMKB; CaMKII beta subunit; CaMKIIB; MGC29528; Proline rich calmodulin dependent protein kinase; CaM kinase II; Calcium/calmodulin-dependent protein; CaM kinase II gamma subunit; CaM-kinase II gamma chain; CaM kinase II delta subunit; CaM-kinase II delta chain; CAM2; CAMK; CAMK-II; CAMK2D; CAMK2G; CAMK2N2; CAMKD; CAMKG; KCC2B; kinase CaMK2-beta.  
研究領域腫瘤  神經(jīng)生物學  信號轉(zhuǎn)導  細胞周期蛋白  激酶和磷酸酶  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat, 
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量53-73kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CaMK2 beta/ gamma/ delta:1-100/479 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

Function:
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplamic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.

Subunit:
CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.

Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Tissue Specificity:
Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Post-translational modifications:
Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Contains 1 protein kinase domain.

SWISS:
Q9UQM7

Gene ID:
815

Database links:

Entrez Gene: 815 Human

Entrez Gene: 816 Human

Entrez Gene: 817 Human

Entrez Gene: 108058 Mouse

Entrez Gene: 12322 Mouse

Entrez Gene: 12323 Mouse

Entrez Gene: 24245 Rat

Entrez Gene: 24246 Rat

Entrez Gene: 25400 Rat

Omim: 114078 Human

Omim: 607707 Human

Omim: 607708 Human

SwissProt: Q13554 Human

SwissProt: Q13557 Human

SwissProt: Q9UQM7 Human

SwissProt: P11798 Mouse

SwissProt: P28652 Mouse

SwissProt: Q6PHZ2 Mouse

SwissProt: P08413 Rat

SwissProt: P11275 Rat

SwissProt: P15791 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CaMK2b也是絲/蘇氨基酸激酶的一種，同屬于Ca++/鈣調(diào)素依賴性蛋白質(zhì)激酶家族成員。鈣／鈣調(diào)素依賴性蛋白激酶Ⅱb（CaMKⅡb）廣泛分布于中樞神經(jīng)系統(tǒng)內(nèi)，參與調(diào)節(jié)神經(jīng)遞質(zhì)的合成釋放、信號轉(zhuǎn)導和突觸可塑性的形成以及磷酸化蛋白