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熱休克蛋白70抗體
  • 產品貨號：
    BN41518R
  • 中文名稱：
    熱休克蛋白70抗體
  • 英文名稱：
    Rabbit anti-HSP70 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41518R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow,Rabbit,Sheep) 推薦應用：WB,IHC-P,ICC,Flow-Cyt,ELISA

  • BN41518R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow,Rabbit,Sheep) 推薦應用：WB,IHC-P,ICC,Flow-Cyt,ELISA

  • BN41518R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Mouse,Rat(predicted:Chicken,Cow,Rabbit,Sheep) 推薦應用：WB,IHC-P,ICC,Flow-Cyt,ELISA

產品描述

英文名稱HSP70
中文名稱熱休克蛋白70抗體
別    名HSP70; HSP-70; HSP 70; Heat shock 70 kDa protein 1; heat shock 70kDa protein 1A; Heat shock 70kDa protein 1B; Heat shock induced protein; heat shock protein 70; HSP70 1; HSP70 2; HSP70.1; HSP72; HSPA1; HSPA1A; HSPA1B; XXbac BCX40G17.3 001; Heat shock 70 kDa protein 1A/1B; HSP71A_HUMAN; Hspa1a; Hsp70-1; HSP72; Hspa1; Hspa1b; Heat shock 70 kDa protein 1A/1B; shock 70 kDa protein 1/2; HSP70-1/HSP70-2; HSP70.1/HSP70.2.




研究領域腫瘤  細胞生物  免疫學  信號轉導  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Chicken, Cow, Rabbit, Sheep, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=1ug/Test ICC=1:100 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量70kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human HSP70 around the phosphorylation site of Tyr41:500-600/641 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].

Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

Subunit:
Component of the CatSper complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts with CHCHD3.

Subcellular Location:
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Tissue Specificity:
HSPA1B is testis-specific.

Similarity:
Belongs to the heat shock protein 70 family.

SWISS:
P0DMV8

Gene ID:
3303

Database links:

Entrez Gene: 281825 Cow

Entrez Gene: 3303 Human

Entrez Gene: 3304 Human

Entrez Gene: 15511 Mouse

Entrez Gene: 193740 Mouse

Entrez Gene: 24472 Rat

Entrez Gene: 294254 Rat

Omim: 140550 Human

Omim: 603012 Human

SwissProt: Q27975 Cow

SwissProt: P0DMV8 Human

SwissProt: P0DMV9 Human

SwissProt: P17879 Mouse

SwissProt: Q61696 Mouse

SwissProt: Q07439 Rat

Unigene: 274402 Human

Unigene: 719966 Human

Unigene: 728810 Human

Unigene: 1950 Rat

Unigene: 228225 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HSP-70是細胞受應激原刺激后誘導產生的一組應激蛋白，與腫瘤發(fā)生、增殖及分化有關。 環(huán)境和病生理性應激原均可導致肌體合成一組應急蛋白既熱休克蛋白。許多熱休克蛋白，包括HSP70家族成員，均參與蛋白的變性-復性、折疊-解折疊、運輸-易位、活化-非活化和分泌等過程。 HSP70與類固醇受體、肌動蛋白、P53等蛋白密切相關。HSP70還參與熱應激原、細胞毒藥物和其他損傷所引起的應急反應，對機體起一定的保護作用。