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熱休克蛋白-60/groEL抗體
  • 產(chǎn)品貨號(hào)：
    BN41506R
  • 中文名稱：
    熱休克蛋白-60/groEL抗體
  • 英文名稱：
    Rabbit anti-HSP60 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41506R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41506R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41506R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱HSP60
中文名稱熱休克蛋白-60/groEL抗體
別    名HSP 60; HSP-60; 60 kDa chaperonin;60 kDa heat shock protein mitochondrial; 60kDa; cb863; Chaperonin 60; Chaperonin;Chaperonin, 60-KD; CPN 60; CPN60; fa04a05; fb22d10;fi27b05; GROEL; GroEL Homolog; GroEL, E. coli, homolog of; Heat shock 60kD protein 1 (chaperonin); Heat shock 60kD protein 1 chaperonin; heat shock 60kDa protein 1 (chaperonin); Heat Shock Protein 60; Heat shock protein 65; HLD4;Hsp 60;HSP 65; HSP65; HSPD 1; HSPD1; HuCHA60; id:ibd2197; Mitochondrial matrix protein P1; P60 lymphocyte protein; sb:cb144; Short heat shock protein 60 Hsp60s1; 60 kDa heat shock protein, mitochondrial; 60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; CH60_HUMAN.  






研究領(lǐng)域腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  線粒體  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量58kDa
細(xì)胞定位細(xì)胞漿 線粒體
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human HSP60:501-573/573 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.

Function:
Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.

Subunit:
Interacts with HRAS (By similarity). Interacts with HBV protein X and HTLV-1 protein p40tax. Interacts with ATAD3A.

Subcellular Location:
Mitochondrion matrix.

DISEASE:
Spastic paraplegia autosomal dominant 13 (SPG13) [MIM:605280]: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Note=The disease is caused by mutations affecting the gene represented in this entry.
Leukodystrophy, hypomyelinating, 4 (HLD4) [MIM:612233]: A severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurs within the first two decades of life. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the chaperonin (HSP60) family.

SWISS:
P10809

Gene ID:
3329

Database links:

Entrez Gene: 3329 Human

Entrez Gene: 15510 Mouse

Entrez Gene: 63868 Rat

Omim: 118190 Human

SwissProt: P86206 Hamster

SwissProt: P10809 Human

SwissProt: P63038 Mouse

SwissProt: P63039 Rat

Unigene: 595053 Human

Unigene: 727543 Human

Unigene: 1777 Mouse

Unigene: 102058 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號(hào)傳導(dǎo)（Signaling Intermediates）
HSP60是一類進(jìn)化上高度保守的蛋白質(zhì)家族.生理狀態(tài)時(shí)協(xié)助多肽或蛋白質(zhì)的正確轉(zhuǎn)位、折疊和裝配,起"分子伴侶"的作用;在應(yīng)激狀態(tài)下,HSP60過表達(dá)或異位表達(dá),作為一種自身抗原被免疫系統(tǒng)識(shí)別,誘發(fā)機(jī)體的保護(hù)性免疫應(yīng)答,也可作為一種信號(hào)分子,在信號(hào)轉(zhuǎn)導(dǎo)中發(fā)揮作用.
該蛋白與腫瘤的發(fā)生、增殖及分化有關(guān)，主要用于舌鱗癌、結(jié)腸癌、胰腺癌和乳腺癌的研究，近年來(lái)研究證實(shí)HSP60在自身免疫性疾病、傳染病、動(dòng)脈粥樣硬化及慢性感染的發(fā)病中均發(fā)揮重要的作用。
HSP-60熱休克蛋白-蛋白質(zhì)折疊過程的引導(dǎo)因子

分子伴侶是一種引導(dǎo)蛋白質(zhì)正確折疊的蛋白質(zhì)。當(dāng)?shù)鞍踪|(zhì)折疊時(shí)，它們能保護(hù)蛋白質(zhì)分子免受其它蛋白質(zhì)的干擾。很多分子伴侶屬于熱休克蛋白（例如HSP-60），它們?cè)诩?xì)胞受熱時(shí)大量合成。熱激可導(dǎo)致蛋白質(zhì)穩(wěn)定性降低，增加錯(cuò)誤折疊的幾率，因此在受到熱刺激時(shí)，細(xì)胞中的蛋白質(zhì)需要更多熱休克蛋白的幫助。
HSP-60是一種典型的分子伴侶，它可以為正在折疊的蛋白質(zhì)提供一個(gè)附著環(huán)境，從而起到保護(hù)折疊過程的作用。