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ChAT膽堿乙酰轉(zhuǎn)移酶抗體
  • 產(chǎn)品貨號(hào)：
    BN41470R
  • 中文名稱：
    ChAT膽堿乙酰轉(zhuǎn)移酶抗體
  • 英文名稱：
    Rabbit anti-ChAT Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41470R-50ul

    50ul

    ￥1486.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41470R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41470R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Pig,Dog) 推薦應(yīng)用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱ChAT
中文名稱ChAT膽堿乙酰轉(zhuǎn)移酶抗體
別    名Choline O acetyltransferase; Choline O acetyltransferase; Acetyl CoA choline O acetyltransferase; Acetyl CoA:choline O acetyltransferase; ChAT; CHOACTase; Choline acetylase; choline acetyltransferase; CMS1A; CMS1A2; EC 2.3.1.6; OTTHUMP00000019583; OTTHUMP00000019584; CLAT_HUMAN.  



研究領(lǐng)域神經(jīng)生物學(xué)  Alzheimer's  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:200-800 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量82kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ChAT:101-200/748 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010].

Function:
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.

DISEASE:
Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.

Similarity:
Belongs to the carnitine/choline acetyltransferase family.

SWISS:
P28329

Gene ID:
1103

Database links:

Entrez Gene: 1103 Human

Entrez Gene: 12647 Mouse

Entrez Gene: 290567 Rat

Omim: 118490 Human

SwissProt: P28329 Human

SwissProt: Q03059 Mouse

SwissProt: P32738 Rat

Unigene: 302002 Human

Unigene: 442817 Mouse

Unigene: 45116 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

膽堿乙酰轉(zhuǎn)移酶是一種在神經(jīng)元胞體內(nèi)合成的酶。當(dāng)該轉(zhuǎn)移酶被合成以后，通過軸質(zhì)流動(dòng)方式轉(zhuǎn)移到神經(jīng)軸突末端。其功能是將乙酰輔酶A轉(zhuǎn)移到膽堿上，導(dǎo)致神經(jīng)遞質(zhì)乙酰膽堿的形成。膽堿能系統(tǒng)參與多種神經(jīng)功能。一些膽堿能神經(jīng)元的改變能導(dǎo)致阿爾茨海默病的發(fā)生。
膽堿乙酰轉(zhuǎn)移酶通常被用來標(biāo)記神經(jīng)元。