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硫氧還蛋白單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN41421M
  • 中文名稱：
    硫氧還蛋白單克隆抗體
  • 英文名稱：
    Mouse anti-Trx-Tag Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN41421M-100ul

    100ul

    ￥1360.00

    交叉反應(yīng)：Human,Pig,Species independent 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱Trx-Tag
中文名稱硫氧還蛋白單克隆抗體
別    名Thioredoxin; ADF; Surface associated sulphydryl protein; Thioredoxin-1; Thioredoxin 1; Thioredoxin1; TXN protein; ADF; ATL derived factor; DKFZp686B1993; MGC61975; SASP; Surface associated sulphydryl protein; Surface-associated sulphydryl protein; TRDX; TRX 1; TRX; TRX1; TXN; TXN; ATL derived factor; ATL-derived factor; THIO_HUMAN; zgc:92903; Trx-Tag.  
產(chǎn)品類型標(biāo)簽抗體 
研究領(lǐng)域腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Mouse
克隆類型Monoclonal
克 隆 號(hào)7G10
交叉反應(yīng)Recombinant protein
產(chǎn)品應(yīng)用WB=1:1000-5000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量12kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Thioredoxin: 
亞    型IgG
純化方法affinity purified by Protein G
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Function:
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

Subunit:
Homodimer; disulfide-linked. Interacts with TXNIP through the redox-active site. Interacts with MAP3K5 and CASP3. In case of infection, interacts with S.typhimurium protein slrP. Interacts with APEX1; the interaction stimulates the FOS/JUN AP-1 DNA-binding activity in a redox-dependent manner.

Subcellular Location:
Nucleus. Cytoplasm. Secreted. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus.

Similarity:
Belongs to the thioredoxin family. Contains 1 thioredoxin domain.

SWISS:
P10599

Gene ID:
7295

Database links:

Entrez Gene: 7295 Human

Entrez Gene: 22166 Mouse

Entrez Gene: 116484 Rat

Omim: 187700 Human

SwissProt: P10599 Human

SwissProt: P10639 Mouse

SwissProt: P11232 Rat

Unigene: 435136 Human

Unigene: 260618 Mouse

Unigene: 29777 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.