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磷酸化血清應(yīng)答因子抗體
  • 產(chǎn)品貨號(hào)：
    BN41396R
  • 中文名稱：
    磷酸化血清應(yīng)答因子抗體
  • 英文名稱：
    Rabbit anti-Phospho-SRF (Ser77) Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41396R-100ul

    100ul

    ￥2470.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Cow,Pig,Dog) 推薦應(yīng)用：IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱Phospho-SRF (Ser77)
中文名稱磷酸化血清應(yīng)答因子抗體
別    名Serum Response Factor SRF (phospho S77); SRF (phospho Ser77); P-SRF (Ser77); c fos serum response element binding factor; Serum Response Factor SRF; c fos serum response element binding transcription factor; ELK3; ERP; MCM 1; MCM-1; MCM1; OTTHUMP00000039820; SAP2; Serum response factor; SRF; SRF serum response factor c fos serum response element binding transcription factor; SRF_HUMAN.  
產(chǎn)品類型磷酸化抗體 
研究領(lǐng)域腫瘤  干細(xì)胞  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human SRF around the phosphorylation site of Ser77 :LY(p-S)GS 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].

Function:
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Subunit:
Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1. Forms a nuclear ternary complex with MKL1 and SCAI.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by PRKDC.

Similarity:
Contains 1 MADS-box domain.

SWISS:
P31948

Gene ID:
6722

Database links:

Entrez Gene: 6722 Human

Entrez Gene: 20807 Mouse

Entrez Gene: 501099 Rat

Omim: 600589 Human

SwissProt: P11831 Human

SwissProt: Q9JM73 Mouse

Unigene: 520140 Human

Unigene: 45044 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

血清應(yīng)答因子(SRF)是一種轉(zhuǎn)錄因子蛋白，可以結(jié)合啟動(dòng)子DNA序列中的血清應(yīng)答元件(SRE)，調(diào)節(jié)一系列基因的表達(dá)，包括即刻早期基因的表達(dá)，如c-fos、fosB、junB、egr-1、egr-2，以及神經(jīng)元基因nurr1、肌肉基因如肌動(dòng)蛋白、肌球蛋白基因等.