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葡萄糖神經(jīng)酰胺合成酶抗體
  • 產(chǎn)品貨號：
    BN41340R
  • 中文名稱：
    葡萄糖神經(jīng)酰胺合成酶抗體
  • 英文名稱：
    Rabbit anti-Ceramide glucosyltransferase Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41340R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,ELISA

  • BN41340R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：WB,IHC-P,ELISA

產(chǎn)品描述

英文名稱Ceramide glucosyltransferase
中文名稱葡萄糖神經(jīng)酰胺合成酶抗體
別    名CEGT_HUMAN; UGCG; GCS; GLCT 1; GLCT-1; GLCT1; Glucosylceramide synthase; UDP glucose ceramide glucosyltransferase; UDP glucose N acylsphingosine D glucosyltransferase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase; Ugcg.  
研究領(lǐng)域腫瘤  細胞生物  細胞凋亡  細胞分化  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量45kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human UGCG:31-98/394 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Glucosylceramide synthase (GCS), also designated ceramide glucosyltransferase, belongs to the glycosyltransferase 2 family. It is a widely expressed integral membrane protein encoded by UGCG. The enzyme can be found in the plasma membrane of all eukaryotic cells, and a significant concentration of glucosylceramide synthase activity has been reported in the Golgi complex. Glucosylceramide synthase catalyzes the first glycosylation step in glycosphingolipid biosynthesis and functions as a glucosyltransferase and flippase in the transfer of glucose to ceramide. Glucosylceramide synthase operates in cell recognition, cell proliferation and differentiation, immune recognition and signal transduction. The regulation of ceramide levels through glucosylceramide synthase has been associated with the induction of apoptosis and notable research implicates this relationship with drug-induced apoptosis in a variety of cell types.

Function:
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase".

Subcellular Location:
Golgi apparatus membrane.

Tissue Specificity:
Found in all tissues examined.

Similarity:
Belongs to the glycosyltransferase 2 family.

SWISS:
Q16739

Gene ID:
7357

Database links:

Entrez Gene: 7357 Human

Entrez Gene: 22234 Mouse

Entrez Gene: 83626 Rat

Omim: 602874 Human

SwissProt: Q16739 Human

SwissProt: O88693 Mouse

SwissProt: Q9R0E0 Rat

Unigene: 304249 Human

Unigene: 593014 Human

Unigene: 198803 Mouse

Unigene: 24091 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.