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F-box蛋白家族FBXO25抗體
  • 產(chǎn)品貨號：
    BN41330R
  • 中文名稱：
    F-box蛋白家族FBXO25抗體
  • 英文名稱：
    Rabbit anti-FBXO25 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41330R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Pig,Rabbit) 推薦應用：WB,ELISA

  • BN41330R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Pig,Rabbit) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱FBXO25
中文名稱F-box蛋白家族FBXO25抗體
別    名F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25; MGC20256; MGC51975; OTTHUMP00000115399;   
研究領域細胞生物  免疫學  信號轉導  轉錄調(diào)節(jié)因子  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Pig, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FBXO25:55-150/367 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹FBXO25 is a member of the F box protein family which is characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1 cullin F box), which function in phosphorylation dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD 40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein protein interaction modules or no recognizable motifs. FBXO25 belongs to the Fbxs class. There are three named isoforms produced by alternative splicing.
FBXO25, also known as FBX25, is a 367 amino acid protein that contains one C-terminal F-box domain and belongs to the Fbx class of the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Expressed at high levels in brain, FBXO25 localizes predominantly to the nucleus and directly interacts with Skp1 p19 and CUL-1. Disruption of the gene encoding FBXO25 can lead to X-linked mental retardation.

Function:
Substrate-recognition component of the SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mayplay a role in accumulation of expanded polyglutamine (polyQ)protein huntingtin (HTT) (By similarity).

Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complexconsisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly withSKP1 and CUL1. Interacts (via C-terminus) with beta-actin (viaN-terminus).

Subcellular Location:
Nuclear. Note=In the nucleus, associateswith a subnuclear dot-like structure. Colocalized with SKP1

Tissue Specificity:
Expressed in all brain tissue observed.

DISEASE:
Note=A chromosomal aberration involving FBXO25 is a causeof X-linked mental retardation (XLMR). Translocationt(X;8)(p11.22;p23.3) with SHROOM4.

Similarity:
Contains 1 F-box domain.

SWISS:
Q8TCJ0

Gene ID:
26260

Database links:

Entrez Gene: 26260 Human

Entrez Gene: 66822 Mouse

Entrez Gene: 364637 Rat

Omim: 609098 Human

SwissProt: Q1RMS8 Cow

SwissProt: Q8TCJ0 Human

SwissProt: Q9D2Y6 Mouse

SwissProt: Q641X7 Rat

Unigene: 438454 Human

Unigene: 37950 Mouse

Unigene: 3663 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.





















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