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核轉錄因子X盒結合蛋白1抗體
  • 產(chǎn)品貨號：
    BN41321R
  • 中文名稱：
    核轉錄因子X盒結合蛋白1抗體
  • 英文名稱：
    Rabbit anti-NFX1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41321R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB,ELISA

  • BN41321R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat) 推薦應用：WB,ELISA

產(chǎn)品描述

英文名稱NFX1
中文名稱核轉錄因子X盒結合蛋白1抗體
別    名NFX2; MGC20369; NFX 1; NFX1; Nuclear transcription factor X box binding 1; Nuclear transcription factor X box binding protein 1; Transcriptional repressor NF X1; NFX1_HUMAN.  
研究領域細胞生物  免疫學  信號轉導  轉錄調節(jié)因子  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量124kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human NFX1:881-980/1120 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹NFX1 is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. It may play a role in the inflammatory response, regulating its duration by limiting the period in which class II MHC molecules are induced by IFN gamma. The RING type zinc finger domain interacts with an ubiquitin conjugating enzyme (E2) and facilitates ubiquitination.

Function:
Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.

Subunit:
Isoform 1 and isoform 3 interact with human papillomavirus (HPV) type-16 E6 oncoprotein. Isoform 1 interacts with PABPC1 and PABPC4.

Subcellular Location:
Nucleus.

Post-translational modifications:
Isoform 3 is polyubiquitinated in the presence of HPV16 E6 protein; which leads to proteasomal degradation. Isoform 1 is not polyubiquitinated.

Similarity:
Belongs to the NFX1 family.
Contains 8 NF-X1-type zinc fingers.
Contains 1 R3H domain.
Contains 1 RING-type zinc finger.

SWISS:
Q12986

Gene ID:
4799

Database links:

Entrez Gene: 4799 Human

Entrez Gene: 74164 Mouse

Omim: 603255 Human

SwissProt: Q12986 Human

SwissProt: B1AY10 Mouse

Unigene: 413074 Human

Unigene: 247456 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.