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轉(zhuǎn)錄增強因子TEF4抗體
  • 產(chǎn)品貨號：
    BN41310R
  • 中文名稱：
    轉(zhuǎn)錄增強因子TEF4抗體
  • 英文名稱：
    Rabbit anti-TEF4 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41310R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse(predicted:Rabbit,Horse,Cow,Dog,Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41310R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse(predicted:Rabbit,Horse,Cow,Dog,Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱TEF4
中文名稱轉(zhuǎn)錄增強因子TEF4抗體
別    名Embryonic TEA domain containing factor; Etdf; ETEF 1; ETF; TEA domain family member 2; TEAD 2; TEAD-2; TEAD2; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b); TEAD2_HUMAN; TEF 4; TEF4; Transcriptional enhancer factor 4; Transcriptional enhancer factor TEF 4; Transcriptional enhancer factor TEF-4.  
研究領(lǐng)域細胞生物  免疫學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量49kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human TEA domain family member 2:235-340/447 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹TEF-4 is strongly coexpressed with TEF-1 in mouse mitotic neuroblasts and is also detected in the gut and the nephrogenic region of the kidney. TEF-4 associates with the powerful transcriptional coactivator YAP65 to mediate mitogenic signals. In addition, TEF-4 promotes the activation of the CTP:phosphocholine cytidylyltransferase (CCT) alpha protein, which is the rate-limiting enzyme of phosphatidylcholine biosynthesis, by enhancing the transcriptional activity of Ets-1.

Function:
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Subunit:
Interacts with YAP1 and WWTR1/TAZ.

Subcellular Location:
Nucleus.

Similarity:
Contains 1 TEA DNA-binding domain.

SWISS:
Q15562

Gene ID:
8463

Database links:

Entrez Gene: 8463 Human

Entrez Gene: 21677 Mouse

Entrez Gene: 308582 Rat

Omim: 601729 Human

SwissProt: Q15562 Human

SwissProt: P48301 Mouse

Unigene: 515534 Human

Unigene: 3019 Mouse

Unigene: 130442 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.