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前細(xì)胞脹亡受體誘導(dǎo)膜損傷蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41261R
  • 中文名稱：
    前細(xì)胞脹亡受體誘導(dǎo)膜損傷蛋白抗體
  • 英文名稱：
    Rabbit anti-Porimin Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41261R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41261R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Dog,Pig,Cow,Horse) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱Porimin
中文名稱前細(xì)胞脹亡受體誘導(dǎo)膜損傷蛋白抗體
別    名KCT3; Keratinocytes associated transmembrane protein 3; Pro oncosis receptor inducing membrane injury; Serine/threonine rich receptor; TMEM123; Transmembrane protein 123; PORIM_HUMAN.  
研究領(lǐng)域細(xì)胞生物  細(xì)胞凋亡  激酶和磷酸酶  細(xì)胞膜受體  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Porimin:101-180/208 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti PORIMIN (pro oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.

Function:
Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Ubiquitous. Not expressed in ovary. Expressed in keratinocytes.

Similarity:
Belongs to the CD164 family.

SWISS:
Q8N131

Gene ID:
114908

Database links:

Entrez Gene: 114908 Human

Omim: 606356 Human

SwissProt: Q8N131 Human

SwissProt: Q96QV2 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.