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細(xì)胞表面免疫球蛋白樣轉(zhuǎn)錄因子4抗體
  • 產(chǎn)品貨號(hào)：
    BN41249R
  • 中文名稱：
    細(xì)胞表面免疫球蛋白樣轉(zhuǎn)錄因子4抗體
  • 英文名稱：
    Rabbit anti-LILRB2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號(hào)

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  • BN41249R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,ELISA

  • BN41249R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,ELISA

產(chǎn)品描述

英文名稱LILRB2
中文名稱細(xì)胞表面免疫球蛋白樣轉(zhuǎn)錄因子4抗體
別    名CD85D; CD85 antigen-like family member D; CD85d; CD85d antigen; ILT 4; ILT-4; ILT4; Immunoglobulin like transcript 4; Immunoglobulin-like transcript 4; Leukocyte immunoglobulin like receptor 2; Leukocyte immunoglobulin like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor 2; Leukocyte immunoglobulin-like receptor subfamily B member 2; Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRA6; LILRB2; LIR 2; LIR-2; LIR2; LIRb; LIRB2_HUMAN; MIR 10; MIR-10; MIR10; Monocyte/macrophage immunoglobulin like receptor 10; Monocyte/macrophage immunoglobulin-like receptor 10.  
研究領(lǐng)域細(xì)胞生物  細(xì)胞膜受體  細(xì)胞表面分子  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
細(xì)胞定位細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LILRB2:1-100/598 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. These receptors all contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), have an inhibitory function and are type I membrane proteins. When they bind to MHC (or other ligands) and ITIM is tyrosine phosphorylated, protein-tyrosine phosphatases are recruited and an inhibitory signal cascade triggered. ILT-4, also designated LIR-2, MIR-10 or CD85D antigen, competes with CD8A for binding to class I MHC antigens.

Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.

Post-translational modifications:
Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.

Similarity:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

SWISS:
Q8N423

Gene ID:
10288

Database links:

Entrez Gene: 10288 Human

Omim: 604815 Human

SwissProt: Q8N423 Human

Unigene: 655652 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.