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內質網(wǎng)核信號轉導蛋白2抗體
  • 產(chǎn)品貨號：
    BN41233R
  • 中文名稱：
    內質網(wǎng)核信號轉導蛋白2抗體
  • 英文名稱：
    Rabbit anti-ERN2 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN41233R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推薦應用：Flow-Cyt,ELISA

  • BN41233R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse(predicted:Human,Rat,Dog,Pig,Cow,Sheep) 推薦應用：Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱ERN2
中文名稱內質網(wǎng)核信號轉導蛋白2抗體
別    名IRE1b; Endoplasmic reticulum to nucleus signaling 2; ER to nucleus signalling 2; ERN 2; Ern1; hIRE2p; Inositol requiring 1 beta; Inositol requiring protein 2; Ire1; Ire1 beta; IRE1 S. cerevisiae homolog of; IRE2; Serine/threonine protein kinase/endoribonuclease IRE2; ERN2_HUMAN.  
研究領域細胞生物  信號轉導  細胞凋亡  轉錄調節(jié)因子  激酶和磷酸酶  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Sheep, )
產(chǎn)品應用ELISA=1:5000-10000 Flow-Cyt=2ug/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量98kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ERN2:465-550/926 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹ERN2, endoplasmic reticulum to nucleus signaling 2, induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. It is pro-apoptotic and appears to play no role in the unfolded-protein response, unlike closely related proteins.

Function:
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 KEN domain.
Contains 1 protein kinase domain.

SWISS:
O75460

Gene ID:
10595

Database links:

Entrez Gene: 10595 Human

Entrez Gene: 26918 Mouse

Omim: 604034 Human

SwissProt: O75460 Human

SwissProt: Q9EQY0 Mouse

Unigene: 133982 Human

Unigene: 20452 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.











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