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候選腫瘤抑制基因MARVELD1抗體
  • 產(chǎn)品貨號(hào)：
    BN41217R
  • 中文名稱：
    候選腫瘤抑制基因MARVELD1抗體
  • 英文名稱：
    Rabbit anti-MARVELD1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41217R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN41217R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rabbit) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱MARVELD1
中文名稱候選腫瘤抑制基因MARVELD1抗體
別    名GB14; MARVD1; MARVEL (membrane-associating) domain containing 1; MARVEL domain containing protein 1; MRVLDC1; Putative MARVEL domain containing protein 1; MALD1_HUMAN.  
研究領(lǐng)域腫瘤  腫瘤細(xì)胞生物標(biāo)志物  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human MARVELD1:31-130/173 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.

Function:
Microtubule-associated protein that exhibits cell cycle-dependent localization and can inhibit cell proliferation and migration

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Observed in the nucleus and at the perinuclear region during interphase, but localizes at the mitotic spindle and midbody at metaphase. A significant fraction of MARVELD1 translocates to the plasma membrane during anaphase or upon microtubule depolymerization.

Tissue Specificity:
Widely expressed in normal tissues. Down-regulated in multiple primary tumors.

Similarity:
Contains 1 MARVEL domain.

SWISS:
Q9BSK0

Gene ID:
83742

Database links:

Entrez Gene: 83742 Human

Entrez Gene: 277010 Mouse

Entrez Gene: 309375 Rat

SwissProt: Q9BSK0 Human

SwissProt: Q7TQJ1 Mouse

Unigene: 209614 Human

Unigene: 206250 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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