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酸性線粒體肌酸激酶抗體
  • 產(chǎn)品貨號(hào)：
    BN41216R
  • 中文名稱：
    酸性線粒體肌酸激酶抗體
  • 英文名稱：
    Rabbit anti-CKMT Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41216R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41216R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Rat,Mouse,Human(predicted:Rabbit,Horse,Cow,Pig,Dog) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱CKMT
中文名稱酸性線粒體肌酸激酶抗體
別    名Acidic type mitochondrial creatine kinase; CKMT; CKMT1; CKMT1A; CKMT1B; Creatine kinase mitochondrial 1 ubiquitous; Creatine kinase ubiquitous mitochondrial; Mia CK; Ubiquitous mitochondrial creatine kinase; UMTCK; KCRU_HUMAN.  
研究領(lǐng)域腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  腫瘤細(xì)胞生物標(biāo)志物  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量43kDa
細(xì)胞定位細(xì)胞漿 細(xì)胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CKMT:115-220/417 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Function:
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Subunit:
Exists as an octamer composed of four MTCK homodimers.

Subcellular Location:
Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Similarity:
Belongs to the ATP:guanido phosphotransferase family.
Contains 1 phosphagen kinase C-terminal domain.
Contains 1 phosphagen kinase N-terminal domain.

SWISS:
P12532

Gene ID:
1159

Database links:

Entrez Gene: 1159 Human

Entrez Gene: 29593 Rat

Omim: 123290 Human

SwissProt: P12532 Human

Unigene: 425633 Human

Unigene: 155589 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.