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組蛋白H4-K4甲基轉移酶抗體
  • 產(chǎn)品貨號：
    BN41197R
  • 中文名稱：
    組蛋白H4-K4甲基轉移酶抗體
  • 英文名稱：
    Rabbit anti-H3-K4-HMTase SETD7 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41197R-100ul

    100ul

    ￥2360.00

    交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41197R-200ul

    200ul

    ￥3490.00

    交叉反應：Human(predicted:Mouse,Rat,Dog,Pig,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱H3-K4-HMTase SETD7
中文名稱組蛋白H4-K4甲基轉移酶抗體
別    名FLJ21193; H3 K4 HMTase; H3-K4-HMTase SETD7; H4 lysine 4 specific; Histone H3 K4 methyltransferase; Histone H3 lysine 4 specific methyltransferase; Histone H3-K4 methyltransferase SETD7; Histone H4 K4 methyltransferase; Histone lysine N methyltransferase; Histone lysine N methyltransferase H3 lysine 4 specific SET7; Histone-lysine N-methyltransferase SETD7; KIAA1717; KMT7; Lysine methyltransferase; Lysine N-methyltransferase 7; OTTHUMP00000164543; OTTHUMP00000220049; SET 7; SET 7/9; SET 9; SET D7; SET domain containing (lysine methyltransferase) 7; SET domain containing protein 7; SET domain containing protein 8; SET domain-containing protein 7; SET7; SET7/9; SET9; Setd7; SETD7_HUMAN.   
研究領域染色質和核信號  表觀遺傳學  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量41kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7:271-366/366 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

Function:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Subunit:
Interacts with IPF1/PDX-1.

Subcellular Location:
Nucleus. Chromosome (Probable).

Tissue Specificity:
Widely expressed. Expressed in pancreatic islets.

Similarity:
Belongs to the histone-lysine methyltransferase family. SET7 subfamily.
Contains 3 MORN repeats.
Contains 1 SET domain.

SWISS:
Q8WTS6

Gene ID:
80854

Database links:

Entrez Gene: 80854 Human

Entrez Gene: 73251 Mouse

Omim: 606594 Human

SwissProt: Q8WTS6 Human

SwissProt: Q8VHL1 Mouse

Unigene: 480792 Human

Unigene: 192111 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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