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kelch樣蛋白7抗體
  • 產(chǎn)品貨號(hào)：
    BN41180R
  • 中文名稱：
    kelch樣蛋白7抗體
  • 英文名稱：
    Rabbit anti-KLHL7 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41180R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41180R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱KLHL7
中文名稱kelch樣蛋白7抗體
別    名Kelch like protein 7; kelch-like 6; kelch-like 7; kelch/BTB.KLHL7_HUMAN   
研究領(lǐng)域腫瘤  免疫學(xué)  染色質(zhì)和核信號(hào)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量64kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human KLHL7:51-150/856 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010].

Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.

Subunit:
Homodimer. Component of the BCR(KLHL7) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL7 and RBX1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis.

DISEASE:
Defects in KLHL7 are the cause of retinitis pigmentosa type 42 (RP42) [MIM:612943]. A retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Similarity:
Contains 1 BACK (BTB/Kelch associated) domain.
Contains 1 BTB (POZ) domain.
Contains 6 Kelch repeats.

SWISS:
Q8IXQ5

Gene ID:
55975

Database links:

Entrez Gene: 55975 Human

Entrez Gene: 52323 Mouse

Entrez Gene: 362303 Rat

Omim: 611119 Human

SwissProt: Q8IXQ5 Human

SwissProt: Q8BUL5 Mouse

SwissProt: Q5XHZ6 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.